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Symptoms of COVID-19 Outpatients in the United States.
Pullen, Matthew F; Skipper, Caleb P; Hullsiek, Kathy H; Bangdiwala, Ananta S; Pastick, Katelyn A; Okafor, Elizabeth C; Lofgren, Sarah M; Rajasingham, Radha; Engen, Nicole W; Galdys, Alison; Williams, Darlisha A; Abassi, Mahsa; Boulware, David R.
  • Pullen MF; Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
  • Skipper CP; Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
  • Hullsiek KH; School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
  • Bangdiwala AS; School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
  • Pastick KA; Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
  • Okafor EC; Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
  • Lofgren SM; Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
  • Rajasingham R; Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
  • Engen NW; School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA.
  • Galdys A; Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
  • Williams DA; Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
  • Abassi M; Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
  • Boulware DR; Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
Open Forum Infect Dis ; 7(7): ofaa271, 2020 Jul.
Article in English | MEDLINE | ID: covidwho-632358
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Outpatients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Outpatients
2. Fever COEXISTS_WITH Confirmed case
Subject
Fever
Predicate
COEXISTS_WITH
Object
Confirmed case
3. COVID-19 PROCESS_OF Outpatients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Outpatients
4. Fever COEXISTS_WITH Confirmed case
Subject
Fever
Predicate
COEXISTS_WITH
Object
Confirmed case
ABSTRACT

BACKGROUND:

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a novel pathogen causing the current worldwide coronavirus disease 2019 (COVID-19) pandemic. Due to insufficient diagnostic testing in the United States, there is a need for clinical decision-making algorithms to guide testing prioritization.

METHODS:

We recruited participants nationwide for a randomized clinical trial. We categorized participants into 3 groups (1) those with confirmed SARS-CoV-2 infection, (2) those with probable SARS-CoV-2 infection (pending test or not tested but with a confirmed COVID-19 contact), and (3) those with possible SARS-CoV-2 infection (pending test or not tested and with a contact for whom testing was pending or not performed). We compared the frequency of self-reported symptoms in each group and categorized those reporting symptoms in early infection (0-2 days), midinfection (3-5 days), and late infection (>5 days).

RESULTS:

Among 1252 symptomatic persons screened, 316 had confirmed, 393 had probable, and 543 had possible SARS-CoV-2 infection. In early infection, those with confirmed and probable SARS-CoV-2 infection shared similar symptom profiles, with fever most likely in confirmed cases (P = .002). Confirmed cases did not show any statistically significant differences compared with unconfirmed cases in symptom frequency at any time point. The most commonly reported symptoms in those with confirmed infection were cough (82%), fever (67%), fatigue (62%), and headache (60%), with only 52% reporting both fever and cough.

CONCLUSIONS:

Symptomatic persons with probable SARS-CoV-2 infection present similarly to those with confirmed SARS-CoV-2 infection. There was no pattern of symptom frequency over time.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Controlled clinical trial / Diagnostic study / Prognostic study / Randomized controlled trials Topics: Long Covid Language: English Journal: Open Forum Infect Dis Year: 2020 Document Type: Article Affiliation country: Ofid

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Controlled clinical trial / Diagnostic study / Prognostic study / Randomized controlled trials Topics: Long Covid Language: English Journal: Open Forum Infect Dis Year: 2020 Document Type: Article Affiliation country: Ofid