COVID-19 and the male susceptibility: the role of ACE2, TMPRSS2 and the androgen receptor.
Prog Urol
; 30(10): 484-487, 2020 Sep.
Article
in English
| MEDLINE | ID: covidwho-634109
ABSTRACT
COVID-19 is the pandemic that hit the world starting December 2019. Recent studies and international statistics have shown an increased prevalence, morbidity as well as mortality of this disease in male patients compared to female patients. The aim of this brief communication is to describe the pathophysiology of this sex-discrepancy, based on the infectivity mechanism of the coronavirus including the Angiotensin-Converting Enzyme 2 (ACE2), the Type II transmembrane Serine Protease (TMPRSS2), and the androgen receptor. This could help understand the susceptibility of urological patients, especially those receiving androgen deprivation therapy for prostate cancer, and testosterone replacement therapy.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Receptors, Virus
/
Serine Endopeptidases
/
Receptors, Androgen
/
Coronavirus Infections
/
Peptidyl-Dipeptidase A
/
Pandemics
/
Betacoronavirus
Type of study:
Observational study
Limits:
Humans
/
Male
Language:
English
Journal:
Prog Urol
Journal subject:
Urology
Year:
2020
Document Type:
Article
Affiliation country:
J.purol.2020.05.007
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