Your browser doesn't support javascript.
An update on antiviral antibody-based biopharmaceuticals.
Ahangarzadeh, Shahrzad; Payandeh, Zahra; Arezumand, Roghaye; Shahzamani, Kiana; Yarian, Fatemeh; Alibakhshi, Abbas.
  • Ahangarzadeh S; Infectious Diseases and Tropical Medicine Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
  • Payandeh Z; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Arezumand R; Department of Medical Biotechnology and Molecular Science, North Khorasan University of Medical Science, Bojnurd, Iran.
  • Shahzamani K; Isfahan Gastroenterology and Hepatology Research Center (IGHRC), Isfahan University of Medical Sciences, Isfahan, Iran.
  • Yarian F; Cellular and Molecular Biology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran; Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: f.yarian@sbmu.ac.ir.
  • Alibakhshi A; Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. Electronic address: alibakhshi@sbmu.ac.ir.
Int Immunopharmacol ; 86: 106760, 2020 Sep.
Article in English | MEDLINE | ID: covidwho-634138
ABSTRACT
Due to the vastness of the science virology, it is no longer an offshoot solely of the microbiology. Viruses have become as the causative agents of major epidemics throughout history. Many therapeutic strategies have been used for these microorganisms, and in this way the recognizing of potential targets of viruses is of particular importance for success. For decades, antibodies and antibody fragments have occupied a significant body of the treatment approaches against infectious diseases. Because of their high affinity, they can be designed and engineered against a variety of purposes, mainly since antibody fragments such as scFv, nanobody, diabody, and bispecific antibody have emerged owing to their small size and interesting properties. In this review, we have discussed the antibody discovery and molecular and biological design of antibody fragments as inspiring therapeutic and diagnostic agents against viral targets.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Biological Products / Coronavirus Infections / Betacoronavirus / Antibodies, Viral Type of study: Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: Int Immunopharmacol Journal subject: Allergy and Immunology / Pharmacology Year: 2020 Document Type: Article Affiliation country: J.intimp.2020.106760

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Biological Products / Coronavirus Infections / Betacoronavirus / Antibodies, Viral Type of study: Observational study / Prognostic study Limits: Animals / Humans Language: English Journal: Int Immunopharmacol Journal subject: Allergy and Immunology / Pharmacology Year: 2020 Document Type: Article Affiliation country: J.intimp.2020.106760