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Persistent infection and pancytopenia associated with ferret systemic coronaviral disease in a domestic ferret.
Tarbert, Danielle K; Bolin, Lisa L; Stout, Alison E; Schaefer, Deanna M W; Ruby, Rebecca E; Rodriguez-Ramos Fernandez, Julia; Duhamel, Gerald E; Whittaker, Gary R; de Matos, Ricardo.
  • Tarbert DK; Companion Exotic Animal Medicine & Surgery Service, College of Veterinary Medicine, University of California-Davis, Davis, CA (Tarbert).
  • Bolin LL; Departments of Clinical Sciences, Section of Zoological Medicine (de Matos), Biomedical Sciences, Section of Anatomic Pathology (Duhamel), and Microbiology and Immunology (Bolin, Stout, Whittaker), College of Veterinary Medicine, Cornell University, Ithaca, NY.
  • Stout AE; Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN (Schaefer).
  • Schaefer DMW; Veterinary Diagnostic Laboratory, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY (Ruby).
  • Ruby RE; IDEXX Laboratories, Wetherby, West Yorkshire, UK (Rodriguez-Ramos Fernandez).
  • Rodriguez-Ramos Fernandez J; Companion Exotic Animal Medicine & Surgery Service, College of Veterinary Medicine, University of California-Davis, Davis, CA (Tarbert).
  • Duhamel GE; Departments of Clinical Sciences, Section of Zoological Medicine (de Matos), Biomedical Sciences, Section of Anatomic Pathology (Duhamel), and Microbiology and Immunology (Bolin, Stout, Whittaker), College of Veterinary Medicine, Cornell University, Ithaca, NY.
  • Whittaker GR; Department of Biomedical and Diagnostic Sciences, College of Veterinary Medicine, University of Tennessee, Knoxville, TN (Schaefer).
  • de Matos R; Veterinary Diagnostic Laboratory, College of Agriculture, Food and Environment, University of Kentucky, Lexington, KY (Ruby).
J Vet Diagn Invest ; 32(4): 616-620, 2020 Jul.
Article in English | MEDLINE | ID: covidwho-634158
ABSTRACT
Ferret systemic coronaviral disease (FSCD) is a well-established cause of mortality in domestic ferrets. We describe herein novel findings in a case of FSCD that was diagnosed and medically managed following virus detection by immunohistochemical (IHC) staining of surgical biopsy samples. Hematologic changes in this ferret suggested spread of the virus to the bone marrow, which was confirmed by IHC staining of a postmortem sample. Genotyping of the virus indicated that the virus grouped with alphacoronaviruses and was most closely related to ferret enteric coronavirus (FRECV) MSU-2. Our clinical case demonstrates that a FRECV MSU-2-like ferret coronavirus associated previously with the enteric pathotype may cause systemic disease, including bone marrow involvement causing persistent pancytopenia.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pancytopenia / Coronavirus Infections / Ferrets / Alphacoronavirus Type of study: Prognostic study Limits: Animals Language: English Journal: J Vet Diagn Invest Journal subject: Veterinary Medicine Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pancytopenia / Coronavirus Infections / Ferrets / Alphacoronavirus Type of study: Prognostic study Limits: Animals Language: English Journal: J Vet Diagn Invest Journal subject: Veterinary Medicine Year: 2020 Document Type: Article