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Inflammatory Cell Infiltration of Adrenals in COVID-19.
Zinserling, Vsevolod A; Semenova, Natalya Yu; Markov, Alexander G; Rybalchenko, Oksana V; Wang, Jun; Rodionov, Roman N; Bornstein, Stefan R.
  • Zinserling VA; S. P. Botkin Clinical Infectious Diseases Hospital, St. Petersburg, Russia.
  • Semenova NY; V. A. Almasov Scientific Research Center, St. Petersburg, Russia.
  • Markov AG; S. P. Botkin Clinical Infectious Diseases Hospital, St. Petersburg, Russia.
  • Rybalchenko OV; V. A. Almasov Scientific Research Center, St. Petersburg, Russia.
  • Wang J; Department of General Physiology, St. Petersburg State University, St. Petersburg, Russia.
  • Rodionov RN; Faculty of Medicine, Department of General Physiology, St. Petersburg State University, St. Petersburg, Russia.
  • Bornstein SR; Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Horm Metab Res ; 52(9): 639-641, 2020 Sep.
Article in English | MEDLINE | ID: covidwho-634513
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was originated in November-December 2019 in Wuhan, China, and has rapidly spread around the world causing severe health and socioeconomical damage to the entire civilization. The key feature of coronavirus disease 2019 (COVID-19), caused by SARS-CoV-2, is upper respiratory tract infection, which may be complicated by bilateral pneumonia. Angiotensin converting enzyme 2 (ACE2) has been identified as a key host factor, required for virus entry into cells. Interestingly, ACE2 is expressed not only in the respiratory system, but also in the other organs and systems including adrenal glands. Here we provide the first description of the pathomorphological changes in adrenal glands in patients with severe COVID-19 characterized by perivascular infiltration of CD3+ and CD8+ T-lymphocytes. Due to the central role of the adrenals in the stress response of the organism, this finding is of potential clinical relevance, because infection with the SARS-CoV-2 virus might critically impair adrenal function under pathophysiological conditions.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Adrenal Glands / Coronavirus Infections / Betacoronavirus Type of study: Prognostic study Limits: Humans Language: English Journal: Horm Metab Res Year: 2020 Document Type: Article Affiliation country: A-1191-8094

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Adrenal Glands / Coronavirus Infections / Betacoronavirus Type of study: Prognostic study Limits: Humans Language: English Journal: Horm Metab Res Year: 2020 Document Type: Article Affiliation country: A-1191-8094