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Factors affecting stability and infectivity of SARS-CoV-2.
Chan, K-H; Sridhar, S; Zhang, R R; Chu, H; Fung, A Y-F; Chan, G; Chan, J F-W; To, K K-W; Hung, I F-N; Cheng, V C-C; Yuen, K-Y.
  • Chan KH; Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China; State Key Laboratory for Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China; Carol Yu Centre for Inf
  • Sridhar S; Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China; State Key Laboratory for Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China; Carol Yu Centre for Inf
  • Zhang RR; Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China; Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China.
  • Chu H; Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China; State Key Laboratory for Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China; Carol Yu Centre for Inf
  • Fung AY; Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China.
  • Chan G; Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China.
  • Chan JF; Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China; State Key Laboratory for Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China; Carol Yu Centre for Inf
  • To KK; Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China; State Key Laboratory for Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China; Carol Yu Centre for Inf
  • Hung IF; Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China; State Key Laboratory for Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China; Carol Yu Centre for Infecti
  • Cheng VC; Department of Microbiology, Queen Mary Hospital, Hospital Authority, Hong Kong Special Administrative Region, People's Republic of China.
  • Yuen KY; Department of Microbiology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China; State Key Laboratory for Emerging Infectious Diseases, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong, People's Republic of China; Carol Yu Centre for Inf
J Hosp Infect ; 106(2): 226-231, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-635357
Semantic information from SemMedBD (by NLM)
1. Feces LOCATION_OF P4HTM gene|P4HTM
Subject
Feces
Predicate
LOCATION_OF
Object
P4HTM gene|P4HTM
2. Virus Diseases COEXISTS_WITH COVID-19
Subject
Virus Diseases
Predicate
COEXISTS_WITH
Object
COVID-19
3. Feces LOCATION_OF P4HTM gene|P4HTM
Subject
Feces
Predicate
LOCATION_OF
Object
P4HTM gene|P4HTM
4. Virus Diseases COEXISTS_WITH COVID-19
Subject
Virus Diseases
Predicate
COEXISTS_WITH
Object
COVID-19
ABSTRACT

BACKGROUND:

In late 2019, a novel human coronavirus - severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) - emerged in Wuhan, China. This virus has caused a global pandemic involving more than 200 countries. SARS-CoV-2 is highly adapted to humans and readily transmits from person-to-person.

AIM:

To investigate the infectivity of SARS-CoV-2 under various environmental and pH conditions. The efficacies of various laboratory virus inactivation methods and home disinfectants against SARS-CoV-2 were investigated.

METHODS:

The residual virus in dried form or in solution was titrated on to Vero E6 cells on days 0, 1, 3, 5 and 7 after incubation at different temperatures. Viral viability was determined after treatment with various disinfectants and pH solutions at room temperature (20-25oC).

FINDINGS:

SARS-CoV-2 was able to retain viability for 3-5 days in dried form or 7 days in solution at room temperature. SARS-CoV-2 could be detected under a wide range of pH conditions from pH 4 to pH 11 for several days, and for 1-2 days in stool at room temperature but lost 5 logs of infectivity. A variety of commonly used disinfectants and laboratory inactivation procedures were found to reduce viral viability effectively.

CONCLUSION:

This study demonstrated the stability of SARS-CoV-2 on environmental surfaces, and raises the possibility of faecal-oral transmission. Commonly used fixatives, nucleic acid extraction methods and heat inactivation were found to reduce viral infectivity significantly, which could ensure hospital and laboratory safety during the SARS-CoV-2 pandemic.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Virulence / Coronavirus Infections / Severe Acute Respiratory Syndrome / Virus Inactivation / Microbial Viability / Betacoronavirus Limits: Humans Country/Region as subject: Asia Language: English Journal: J Hosp Infect Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Virulence / Coronavirus Infections / Severe Acute Respiratory Syndrome / Virus Inactivation / Microbial Viability / Betacoronavirus Limits: Humans Country/Region as subject: Asia Language: English Journal: J Hosp Infect Year: 2020 Document Type: Article