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Relapsing viral keratoconjunctivitis in COVID-19: a case report.
Guo, Dongyu; Xia, Jianhua; Wang, Yang; Zhang, Xuhong; Shen, Ye; Tong, Jian-Ping.
  • Guo D; Department of Ophthalmology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, 310003, Zhejiang, China.
  • Xia J; Department of Ophthalmology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, 310003, Zhejiang, China.
  • Wang Y; Department of Ophthalmology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, 310003, Zhejiang, China.
  • Zhang X; Department of Ophthalmology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, 310003, Zhejiang, China.
  • Shen Y; Department of Ophthalmology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, 310003, Zhejiang, China. idrshen@zju.edu.cn.
  • Tong JP; Department of Ophthalmology, Zhejiang University School of Medicine First Affiliated Hospital, Hangzhou, 310003, Zhejiang, China. tongjp2000@hotmail.com.
Virol J ; 17(1): 97, 2020 07 08.
Article in English | MEDLINE | ID: covidwho-635654
ABSTRACT

BACKGROUND:

Since the outbreak of Coronavirus Disease 2019 (COVID-19) in December 2019, many studies have reported the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the conjunctival sac of patients infected with this virus, with several patients displaying symptoms of viral conjunctivitis. However, to our best knowledge, there is no in-depth report on the course of patients with COVID-19 complicated by relapsing viral conjunctivitis or keratoconjunctivitis. CASE PRESENTATION A 53-year-old man confirmed with COVID-19 developed symptoms of viral conjunctivitis in the left eye approximately 10 days after the onset of COVID-19. The results of a nucleic acid test were positive for SARS-CoV-2 in the conjunctival sac of the left eye. The symptoms were relieved 6 days after treatment. However, the patient was subsequently diagnosed with viral keratoconjunctivitis in both eyes 5 days after the symptoms in the left eye were satisfactorily relieved. The disease progressed rapidly, with spot staining observed at the periphery of the corneal epithelium. Although SARS-CoV-2 could not be detected in conjunctival secretions, the levels of inflammatory factors, such as interleukin-6, were increased in both eyes. Both eyes were treated with glucocorticoids, and symptoms were controlled within 5 days. There was no recurrence.

CONCLUSIONS:

In this case report, the pathogenesis, clinical manifestations, treatment, and outcome of a case with COVID-19 complicated by relapsing viral keratoconjunctivitis is described, and the involvement of topical cytokine surge in the pathogenesis of COVID-19 as it relates to viral keratoconjunctivitis is reported.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Conjunctivitis, Viral / Coronavirus Infections / Betacoronavirus / Keratoconjunctivitis Type of study: Case report / Experimental Studies / Prognostic study Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Journal: Virol J Journal subject: Virology Year: 2020 Document Type: Article Affiliation country: S12985-020-01370-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Conjunctivitis, Viral / Coronavirus Infections / Betacoronavirus / Keratoconjunctivitis Type of study: Case report / Experimental Studies / Prognostic study Topics: Long Covid Limits: Humans / Male / Middle aged Language: English Journal: Virol J Journal subject: Virology Year: 2020 Document Type: Article Affiliation country: S12985-020-01370-6