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SARS, MERS and COVID-19: clinical manifestations and organ-system complications: a mini review.
Gerges Harb, Jad; Noureldine, Hussein A; Chedid, Georges; Eldine, Mariam Nour; Abdallah, Dany Abou; Chedid, Nancy Falco; Nour-Eldine, Wared.
  • Gerges Harb J; Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
  • Noureldine HA; Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
  • Chedid G; Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
  • Eldine MN; Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
  • Abdallah DA; Lebanese University, Faculty of Medical Sciences, Rafik Hariri University Campus, Hadath, Lebanon.
  • Chedid NF; Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
  • Nour-Eldine W; Gilbert and Rose-Marie Chagoury School of Medicine, Lebanese American University, P.O. Box 36, Byblos, Lebanon.
Pathog Dis ; 78(4)2020 06 01.
Article in English | MEDLINE | ID: covidwho-635704
ABSTRACT
Middle East Respiratory Syndrome (MERS), Severe Acute Respiratory Syndrome (SARS) and Coronavirus Disease 2019 (COVID-19) are caused by three distinct coronaviruses belonging to the same genus. COVID-19 and its two predecessors share many important features in their clinical presentations, and in their propensity for progression to severe disease which is marked by high rates of morbidity and mortality. However, comparison of the three viral illnesses also reveals a number of specific differences in clinical manifestations and complications, which suggest variability in the disease process. This narrative review delineates the pulmonary, cardiac, renal, gastrointestinal, hepatic, neurological and hematologic complications associated with these three respiratory coronaviruses. It further describes the mechanisms of immune hyperactivation-particularly cytokine release syndrome-implicated in the multi-organ system injury seen in severe cases of MERS, SARS and COVID-19.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Severe Acute Respiratory Syndrome Type of study: Diagnostic study / Prognostic study / Reviews Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Femspd

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Severe Acute Respiratory Syndrome Type of study: Diagnostic study / Prognostic study / Reviews Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Femspd