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SARS-CoV-2 viral load and antibody responses: the case for convalescent plasma therapy.
Casadevall, Arturo; Joyner, Michael J; Pirofski, Liise-Anne.
  • Casadevall A; Department of Molecular Microbiology and Immunology, Johns Hopkins School of Public Health, Baltimore, Maryland, USA.
  • Joyner MJ; Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota, USA.
  • Pirofski LA; Division of Infectious Diseases, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.
J Clin Invest ; 130(10): 5112-5114, 2020 10 01.
Article in English | MEDLINE | ID: covidwho-965886
ABSTRACT
Most patients with COVID-19 lack antibody to SARS-CoV-2 in the first 10 days of illness while the virus drives disease pathogenesis. SARS-CoV-2 antibody deficiency in the setting of a tissue viral burden suggests that using an antibody as a therapeutic agent would augment the antiviral immune response. In this issue of the JCI, Wang and collaborators describe the kinetics of viral load and the antibody responses of 23 individuals with COVID-19 experiencing mild and severe disease. The researchers found that (a) individuals with mild and severe disease produced neutralizing IgG to SARS-CoV-2 10 days after disease onset, (b) SARS-CoV-2 persisted longer in those with severe disease, and (c) there was cross-reactivity between antibodies to SARS-CoV-1 and SARS-CoV-2, but only antibodies from patients with COVID-19 neutralized SARS-CoV-2. These observations provide important information on the serological response to SARS-CoV-2 of hospitalized patients with COVID-19 that can inform the use of convalescent plasma therapy.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Severe Acute Respiratory Syndrome / Pandemics Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: J Clin Invest Year: 2020 Document Type: Article Affiliation country: Jci139760

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Severe Acute Respiratory Syndrome / Pandemics Type of study: Observational study / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: J Clin Invest Year: 2020 Document Type: Article Affiliation country: Jci139760