Your browser doesn't support javascript.
Self-reported loss of smell without nasal obstruction to identify COVID-19. The multicenter Coranosmia cohort study.
Salmon Ceron, Dominique; Bartier, Sophie; Hautefort, Charlotte; Nguyen, Yann; Nevoux, Jérôme; Hamel, Anne-Laure; Camhi, Yohan; Canouï-Poitrine, Florence; Verillaud, Benjamin; Slama, Dorsaf; Haim-Boukobza, Stephanie; Sourdeau, Elise; Cantin, Delphine; Corré, Alain; Bryn, Agnes; Etienne, Nicolas; Rozenberg, Flore; Layese, Richard; Papon, Jean-François; Bequignon, Emilie.
  • Salmon Ceron D; Department of Infectious Diseases and Immunology, Hotel Dieu Hospital, Paris Public Hospitals (APHP), 1 Place du Parvis de Notre-Dame, Paris 75004, France; University of Paris, School of Medicine, Paris 75005, France. Electronic address: dominique.salmon@aphp.fr.
  • Bartier S; Department of Oto-rhino-laryngology, Head and Neck Surgery, Intercommunal Hospital of Créteil, Créteil 94000, France; University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APH
  • Hautefort C; Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, Lariboisière Hospital (APHP), Paris 75010, France; University Paris Diderot, School of Medicine, Paris 75010, France.
  • Nguyen Y; Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, AP-HP Sorbonne University Hospital Pitié Salpêtrière Hospital (AP-HP), Paris 75006, France; Sorbonne University, Paris 75013, France.
  • Nevoux J; Groupe Hospitalier Paris-Saclay, Hôpital Bicêtre, Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals. Le Kremlin-Bicêtre 94270, France; Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre F-94275, France.
  • Hamel AL; Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, Lariboisière Hospital (APHP), Paris 75010, France; University Paris Diderot, School of Medicine, Paris 75010, France.
  • Camhi Y; Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, AP-HP Sorbonne University Hospital Pitié Salpêtrière Hospital (AP-HP), Paris 75006, France.
  • Canouï-Poitrine F; University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Clinical Research Unit: (URC-Mondor), Department of Public Health, Henri Mondor Hospital Pa
  • Verillaud B; Department of Oto-rhino-laryngology Head and Neck Surgery, Paris Public Hospitals, Lariboisière Hospital (APHP), Paris 75010, France; University Paris Diderot, School of Medicine, Paris 75010, France.
  • Slama D; Department of Infectious Diseases and Immunology, Hotel Dieu Hospital, Paris Public Hospitals (APHP), 1 Place du Parvis de Notre-Dame, Paris 75004, France.
  • Haim-Boukobza S; Cerba Laboratory, Saint-Ouen L'Aumône, France.
  • Sourdeau E; Emergency Department, Hotel Dieu Hospital, Paris Public Hospitals (APHP), Paris 75004, France.
  • Cantin D; Emergency Department, Hotel Dieu Hospital, Paris Public Hospitals (APHP), Paris 75004, France.
  • Corré A; Department of Oto-rhino-laryngology Head and Neck Surgery, Hopital Rothschild Foundation, Paris, France.
  • Bryn A; University of Paris, School of Medicine, Paris 75005, France; General Medical Practioner, Paris, France.
  • Etienne N; Department of Infectious Diseases and Immunology, Hotel Dieu Hospital, Paris Public Hospitals (APHP), 1 Place du Parvis de Notre-Dame, Paris 75004, France.
  • Rozenberg F; University of Paris, School of Medicine, Paris 75005, France; Virology Department, Cochin Hospital, Paris Public Hospitals (APHP), Paris 75004, France.
  • Layese R; University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Clinical Research Unit: (URC-Mondor), Department of Public Health, Henri Mondor Hospital Pa
  • Papon JF; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APHP), Créteil 94000, France; Centre National de la Recherche Scientifique CNRS, ERL 7000, Créteil 94000, France; Groupe Hospitalier Paris-Saclay, Hôpital Bicêtre, Department of Oto-rhino-laryngology H
  • Bequignon E; Department of Oto-rhino-laryngology, Head and Neck Surgery, Intercommunal Hospital of Créteil, Créteil 94000, France; University Paris-Est Créteil (UPEC), School of Medicine, Créteil 94000, France; INSERM U955, IMRB- CEpiA team, 94000 Créteil, France Paris Public Hospitals Henri Mondor Hospital (APH
J Infect ; 81(4): 614-620, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-635718
ABSTRACT

OBJECTIVES:

To determine the frequency of SARS-CoV-2 positive samples in a subset of patients consulting for primarily isolated acute (<7 days) loss of smell and to assess the diagnostic accuracy of olfactory/gustatory dysfunction for COVID-19 diagnosis in the overall population tested for COVID-19 in the same period.

METHODS:

Prospective multicentric cohort study in four olfactory ENT units and a screening center for COVID-19.

RESULTS:

i) Among a subset of 55 patients consulting for primarily recent loss of smell, we found that 51 (92.7%) had a COVID-19 positive test (median viral load of 28.8 cycle threshold). Loss of smell was mostly total (anosmia), rarely associated with nasal obstruction but associated with a taste disorder in 80%. Olfactory dysfunction occurred suddenly, either as first complaint or preceded by mild symptoms occurring a median of 3 days. The majority of patients (72.9%) partially recovered the sense of smell within 15 days. ii) In a population of 1824 patients tested for COVID-19, the positive predictive value and the specificity of loss of smell and/or taste were 78.5% and 90.3% respectively (sensitivity (40.8%), negative predictive value (63.6%)).

CONCLUSIONS:

Self-reported loss of smell had a high predictive positive value to identify COVID-19. Making this sign well known publicly could help to adopt isolation measures and inform potential contacts.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Taste Disorders / Coronavirus Infections / Olfaction Disorders Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adult / Female / Humans / Male Language: English Journal: J Infect Year: 2020 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Taste Disorders / Coronavirus Infections / Olfaction Disorders Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Limits: Adult / Female / Humans / Male Language: English Journal: J Infect Year: 2020 Document Type: Article