The interface between coronaviruses and host cell RNA biology: Novel potential insights for future therapeutic intervention.
Wiley Interdiscip Rev RNA
; 11(5): e1614, 2020 09.
Article
in English
| MEDLINE | ID: covidwho-637124
ABSTRACT
Coronaviruses, including SARS-Cov-2, are RNA-based pathogens that interface with a large variety of RNA-related cellular processes during infection. These processes include capping, polyadenylation, localization, RNA stability, translation, and regulation by RNA binding proteins or noncoding RNA effectors. The goal of this article is to provide an in-depth perspective on the current state of knowledge of how various coronaviruses interact with, usurp, and/or avoid aspects of these cellular RNA biology machineries. A thorough understanding of how coronaviruses interact with RNA-related posttranscriptional processes in the cell should allow for new insights into aspects of viral pathogenesis as well as identify new potential avenues for the development of anti-coronaviral therapeutics. This article is categorized under RNA in Disease and Development > RNA in Disease.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
RNA, Messenger
/
RNA, Viral
/
MicroRNAs
/
Host-Pathogen Interactions
/
RNA, Long Noncoding
/
Betacoronavirus
/
RNA, Circular
Type of study:
Experimental Studies
Limits:
Animals
/
Humans
Language:
English
Journal:
Wiley Interdiscip Rev RNA
Year:
2020
Document Type:
Article
Affiliation country:
Wrna.1614
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