Potential Benefits of Tryptophan Metabolism to the Efficacy of Tocilizumab in COVID-19.
Front Pharmacol
; 11: 959, 2020.
Article
in English
| MEDLINE | ID: covidwho-637550
ABSTRACT
Tocilizumab has been proposed as a means of opposing hyperinflammatory responses in intensive care patients with COVID-19. Here, we briefly discuss the potentially multiple, synergistic mechanisms whereby tocilizumab might exert therapeutic activity, mostly focusing on the production of tryptophan-derived catabolites that would result from blockade of IL-6 signaling, as contextualized to the cytokine storm occurring in COVID-19 patients.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Language:
English
Journal:
Front Pharmacol
Year:
2020
Document Type:
Article
Affiliation country:
Fphar.2020.00959
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