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The Sensitivity of Respiratory Tract Specimens for the Detection of SARS-CoV-2: A Protocol for a Living Systematic Review and Meta-Analysis.
Moore, Adam J; Nakahata, Maura I; Kalinich, Chaney C; Nyhan, Kate; Bromberg, Daniel J; Shi, Xiaoting; Ko, Albert I; Grubaugh, Nathan D; Casanovas-Massana, Arnau; Wyllie, Anne L.
  • Moore AJ; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA.
  • Nakahata MI; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA.
  • Kalinich CC; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA.
  • Nyhan K; Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, USA.
  • Bromberg DJ; Harvey Cushing / John Hay Whitney Medical Library, Yale University, New Haven, CT, USA.
  • Shi X; Department of Social and Behavioral Sciences, Yale School of Public Health, Yale University, New Haven, CT, USA.
  • Ko AI; Center for Interdisciplinary Research on AIDS, Yale University, New Haven, CT, USA.
  • Grubaugh ND; Department of Environmental Health Sciences, Yale School of Public Health, Yale University, New Haven, CT, USA.
  • Casanovas-Massana A; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA.
  • Wyllie AL; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University, New Haven, CT, USA.
medRxiv ; 2020 Jul 04.
Article in English | MEDLINE | ID: covidwho-637873
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ABSTRACT

BACKGROUND:

Highly sensitive, non-invasive, and easily accessible diagnostics for Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) are essential for the control of the Coronavirus Disease 2019 (COVID-19) pandemic. There is a clear need to establish a gold standard diagnostic for SARS-CoV-2 infection in humans using respiratory tract specimens.

METHODS:

Searches will be conducted in the bibliographic databases Medline, Embase, bioRxiv, medRxiv, F1000, ChemRxiv, PeerJ Preprints, Preprints.org, Beilstein Archive, and Research Square. Relevant government documents and grey literature will be sought on the FDA's Emergency Use Authorizations website, the ECDC's website, and the website of the Foundation for Innovative New Diagnostics. Finally, papers categorized as diagnosis papers by the EPPI Centre's COVID-19 living systematic map will be added to our screening process; those papers are tagged with the diagnosis topic based on human review, rather than database searches, and thus this set of papers might include ones that have not been captured by our search strategy.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Reviews / Systematic review/Meta Analysis Language: English Year: 2020 Document Type: Article Affiliation country: 2020.07.02.20144543

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Diagnostic study / Reviews / Systematic review/Meta Analysis Language: English Year: 2020 Document Type: Article Affiliation country: 2020.07.02.20144543