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Angiotensin Converting Enzyme Inhibitor and Angiotensin II Receptor Blocker Use Among Outpatients Diagnosed With COVID-19.
Bae, David J; Tehrani, David M; Rabadia, Soniya V; Frost, Marlene; Parikh, Rushi V; Calfon-Press, Marcella; Aksoy, Olcay; Umar, Soban; Ardehali, Reza; Rabbani, Amir; Bokhoor, Pooya; Nsair, Ali; Currier, Jesse; Tobis, Jonathan; Fonarow, Gregg C; Dave, Ravi; Rafique, Asim M.
  • Bae DJ; Division of Cardiology, University of California, Los Angeles, California. Electronic address: dbae@mednet.ucla.edu.
  • Tehrani DM; Division of Cardiology, University of California, Los Angeles, California. Electronic address: dtehrani#@mednet.ucla.edu.
  • Rabadia SV; Department of Medicine, University of California, Los Angeles, California.
  • Frost M; Division of Cardiology, University of California, Los Angeles, California.
  • Parikh RV; Division of Cardiology, University of California, Los Angeles, California.
  • Calfon-Press M; Division of Cardiology, University of California, Los Angeles, California.
  • Aksoy O; Division of Cardiology, University of California, Los Angeles, California.
  • Umar S; Department of Anesthesiology, University of California, Los Angeles, California.
  • Ardehali R; Division of Cardiology, University of California, Los Angeles, California.
  • Rabbani A; Division of Cardiology, University of California, Los Angeles, California.
  • Bokhoor P; Division of Cardiology, University of California, Los Angeles, California.
  • Nsair A; Division of Cardiology, University of California, Los Angeles, California.
  • Currier J; Division of Cardiology, University of California, Los Angeles, California; Department of Cardiology, Veterans Affairs Greater Los Angeles Health Care System, Los Angeles, California.
  • Tobis J; Division of Cardiology, University of California, Los Angeles, California.
  • Fonarow GC; Division of Cardiology, University of California, Los Angeles, California.
  • Dave R; Division of Cardiology, University of California, Los Angeles, California.
  • Rafique AM; Division of Cardiology, University of California, Los Angeles, California.
Am J Cardiol ; 132: 150-157, 2020 10 01.
Article in English | MEDLINE | ID: covidwho-638390
ABSTRACT
Coronavirus disease 2019 (COVID-19) is a viral pandemic precipitated by the severe acute respiratory syndrome coronavirus 2. Since previous reports suggested that viral entry into cells may involve angiotensin converting enzyme 2, there has been growing concern that angiotensin converting enzyme inhibitor (ACEI) and angiotensin II receptor blocker (ARB) use may exacerbate the disease severity. In this retrospective, single-center US study of adult patients diagnosed with COVID-19, we evaluated the association of ACEI/ARB use with hospital admission. Secondary outcomes included ICU admission, mechanical ventilation, length of hospital stay, use of inotropes, and all-cause mortality. Propensity score matching was performed to account for potential confounders. Among 590 unmatched patients diagnosed with COVID-19, 78 patients were receiving ACEI/ARB (median age 63 years and 59.7% male) and 512 patients were non-users (median age 42 years and 47.1% male). In the propensity matched population, multivariate logistic regression analysis adjusting for age, gender and comorbidities demonstrated that ACEI/ARB use was not associated with hospital admission (OR 1.2, 95%CI 0.5 to 2.7, p = 0.652). CAD and CKD/end stage renal disease [ESRD] remained independently associated with admission to hospital. All-cause mortality, ICU stay, need for ventilation, and inotrope use was not significantly different between the 2 study groups. In conclusion, among patients who were diagnosed with COVID-19, ACEI/ARB use was not associated with increased risk of hospital admission.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Outpatients / Pneumonia, Viral / Angiotensin-Converting Enzyme Inhibitors / Coronavirus Infections / Angiotensin Receptor Antagonists / Betacoronavirus Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Am J Cardiol Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Outpatients / Pneumonia, Viral / Angiotensin-Converting Enzyme Inhibitors / Coronavirus Infections / Angiotensin Receptor Antagonists / Betacoronavirus Type of study: Cohort study / Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Am J Cardiol Year: 2020 Document Type: Article