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Clinical features in 52 patients with COVID-19 who have increased leukocyte count: a retrospective analysis.
Zhao, Kaochang; Li, Ruiyun; Wu, Xiaojun; Zhao, Yang; Wang, Tao; Zheng, Zhishui; Zeng, Shaolin; Ding, Xuhong; Nie, Hanxiang.
  • Zhao K; Department of Respiratory & Critical Medicine, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan, 430060, China.
  • Li R; Department of Respiratory & Critical Medicine, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan, 430060, China.
  • Wu X; Department of Respiratory & Critical Medicine, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan, 430060, China.
  • Zhao Y; Department of Respiratory & Critical Medicine, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan, 430060, China.
  • Wang T; Department of Respiratory & Critical Medicine, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan, 430060, China.
  • Zheng Z; Department of Respiratory & Critical Medicine, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan, 430060, China.
  • Zeng S; Department of Respiratory & Critical Medicine, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan, 430060, China.
  • Ding X; Department of Respiratory & Critical Medicine, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan, 430060, China.
  • Nie H; Department of Respiratory & Critical Medicine, Renmin Hospital of Wuhan University, 238 Jiefang Road, Wuchang District, Wuhan, 430060, China. nhxbj@sohu.com.
Eur J Clin Microbiol Infect Dis ; 39(12): 2279-2287, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-638599
ABSTRACT
Recent reports have showed that a proportion of patients with Coronavirus Disease 2019 (COVID-19) presented elevated leukocyte count. Clinical data about these patients is scarce. We aimed to evaluate the clinical findings of patients with COVID-19 who have increased leukocyte at admission. We retrospectively collected the clinical data on the 52 patients who have increased leukocyte count at admission from the 619 patients with confirmed COVID-19 who had pneumonia with abnormal features on chest CT scan in Renmin Hospital of Wuhan University in Wuhan, China, from February 3 to March 3, 2020. The mean age of the 52 patients with increased leukocyte count was 64.7 (SD 11.4) years, 32 (61.5%) were men and 47 (90.4%) had fever. Compared with the patients with non-increased leukocyte count, the patients with increased leukocyte count were significantly older (P < 0.01), were more likely to have underlying chronic diseases (P < 0.01), more likely to develop critically illness (P < 0.01), more likely to admit to an ICU (P < 0.01), more likely to receive mechanical ventilation (P < 0.01), had higher rate of death (P < 0.01) and the blood levels of neutrophil count and the serum concentrations of CRP and IL-6 were significantly increased, (P < 0.01). The older patients with COVID-19 who had underlying chronic disorders are more likely to develop leukocytosis. These patients are more likely to develop critical illness, with a high admission to an ICU and a high mortality rate.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Coronary Disease / Diabetes Mellitus / Hypertension / Leukocytes / Leukocytosis Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Language: English Journal: Eur J Clin Microbiol Infect Dis Journal subject: Communicable Diseases / Microbiology Year: 2020 Document Type: Article Affiliation country: S10096-020-03976-8

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Coronary Disease / Diabetes Mellitus / Hypertension / Leukocytes / Leukocytosis Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Language: English Journal: Eur J Clin Microbiol Infect Dis Journal subject: Communicable Diseases / Microbiology Year: 2020 Document Type: Article Affiliation country: S10096-020-03976-8