Endocrine Significance of SARS-CoV-2's Reliance on ACE2.
Endocrinology
; 161(9)2020 09 01.
Article
in English
| MEDLINE | ID: covidwho-639100
ABSTRACT
The current COVID-19 pandemic is the most disruptive event in the past 50 years, with a global impact on health care and world economies. It is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), a coronavirus that uses angiotensin-converting enzyme 2 (ACE2) as an entry point to the cells. ACE2 is a transmembrane carboxypeptidase and member of the renin-angiotensin system. This mini-review summarizes the main findings regarding ACE2 expression and function in endocrine tissues. We discuss rapidly evolving knowledge on the potential role of ACE2 and SARS coronaviruses in endocrinology and the development of diabetes mellitus, hypogonadism, and pituitary and thyroid diseases.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Angiotensin II
/
Peptidyl-Dipeptidase A
/
Diabetes Complications
/
Endocrine System Diseases
/
Betacoronavirus
Topics:
Long Covid
Limits:
Animals
/
Humans
Language:
English
Year:
2020
Document Type:
Article
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