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Immunophenotyping of COVID-19 and influenza highlights the role of type I interferons in development of severe COVID-19.
Lee, Jeong Seok; Park, Seongwan; Jeong, Hye Won; Ahn, Jin Young; Choi, Seong Jin; Lee, Hoyoung; Choi, Baekgyu; Nam, Su Kyung; Sa, Moa; Kwon, Ji-Soo; Jeong, Su Jin; Lee, Heung Kyu; Park, Sung Ho; Park, Su-Hyung; Choi, Jun Yong; Kim, Sung-Han; Jung, Inkyung; Shin, Eui-Cheol.
  • Lee JS; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
  • Park S; Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea.
  • Jeong HW; Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju 28644, Republic of Korea.
  • Ahn JY; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
  • Choi SJ; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
  • Lee H; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
  • Choi B; Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea.
  • Nam SK; Department of Biological Sciences, KAIST, Daejeon 34141, Republic of Korea.
  • Sa M; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
  • Kwon JS; The Center for Epidemic Preparedness, KAIST Institute, Daejeon 34141, Republic of Korea.
  • Jeong SJ; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
  • Lee HK; Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, Republic of Korea.
  • Park SH; Department of Internal Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.
  • Park SH; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
  • Choi JY; The Center for Epidemic Preparedness, KAIST Institute, Daejeon 34141, Republic of Korea.
  • Kim SH; School of Life Sciences, Ulsan National Institute of Science & Technology (UNIST), Ulsan 44919, Republic of Korea.
  • Jung I; Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea.
  • Shin EC; The Center for Epidemic Preparedness, KAIST Institute, Daejeon 34141, Republic of Korea.
Sci Immunol ; 5(49)2020 07 10.
Article in English | MEDLINE | ID: covidwho-639363
Semantic information from SemMedBD (by NLM)
1. Inflammation COEXISTS_WITH COVID-19
Subject
Inflammation
Predicate
COEXISTS_WITH
Object
COVID-19
2. Respiratory Distress Syndrom COEXISTS_WITH C5203670
Subject
Respiratory Distress Syndrom
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COEXISTS_WITH
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C5203670
3. COVID-19 PROCESS_OF Patients
Subject
COVID-19
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PROCESS_OF
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Patients
4. COVID-19 PROCESS_OF Persons
Subject
COVID-19
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PROCESS_OF
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Persons
5. Influenza PROCESS_OF Patients
Subject
Influenza
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PROCESS_OF
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Patients
6. Peripheral blood mononuclear cell (cell) INTERACTS_WITH interleukin-
Subject
Peripheral blood mononuclear cell (cell)
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INTERACTS_WITH
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interleukin-
7. Hyperactive behavior PROCESS_OF Patients
Subject
Hyperactive behavior
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PROCESS_OF
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Patients
8. Inflammation NEG_PROCESS_OF Patients
Subject
Inflammation
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NEG_PROCESS_OF
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9. Patients LOCATION_OF IFNA1
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LOCATION_OF
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IFNA1
10. Pivot AFFECTS Inflammation
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Pivot
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AFFECTS
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Inflammation
11. Inflammation COEXISTS_WITH COVID-19
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Inflammation
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COEXISTS_WITH
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COVID-19
12. Respiratory Distress Syndrome, Adult COEXISTS_WITH COVID-19
Subject
Respiratory Distress Syndrome, Adult
Predicate
COEXISTS_WITH
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COVID-19
13. COVID-19 PROCESS_OF Patients
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COVID-19
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PROCESS_OF
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Patients
14. COVID-19 PROCESS_OF Persons
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COVID-19
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PROCESS_OF
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Persons
15. Influenza PROCESS_OF Patients
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Influenza
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PROCESS_OF
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Patients
16. Peripheral blood mononuclear cell (cell) INTERACTS_WITH interleukin-1, beta
Subject
Peripheral blood mononuclear cell (cell)
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INTERACTS_WITH
Object
interleukin-1, beta
17. Hyperactive behavior PROCESS_OF Patients
Subject
Hyperactive behavior
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PROCESS_OF
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Patients
18. Inflammation NEG_PROCESS_OF Patients
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Inflammation
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NEG_PROCESS_OF
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Patients
19. Patients LOCATION_OF IFNA1
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Patients
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LOCATION_OF
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IFNA1
20. Pivot AFFECTS Inflammation
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Pivot
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AFFECTS
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Inflammation
ABSTRACT
Although most SARS-CoV-2-infected individuals experience mild coronavirus disease 2019 (COVID-19), some patients suffer from severe COVID-19, which is accompanied by acute respiratory distress syndrome and systemic inflammation. To identify factors driving severe progression of COVID-19, we performed single-cell RNA-seq using peripheral blood mononuclear cells (PBMCs) obtained from healthy donors, patients with mild or severe COVID-19, and patients with severe influenza. Patients with COVID-19 exhibited hyper-inflammatory signatures across all types of cells among PBMCs, particularly up-regulation of the TNF/IL-1ß-driven inflammatory response as compared to severe influenza. In classical monocytes from patients with severe COVID-19, type I IFN response co-existed with the TNF/IL-1ß-driven inflammation, and this was not seen in patients with milder COVID-19. Interestingly, we documented type I IFN-driven inflammatory features in patients with severe influenza as well. Based on this, we propose that the type I IFN response plays a pivotal role in exacerbating inflammation in severe COVID-19.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza A virus / Pneumonia, Viral / Severity of Illness Index / Interferon Type I / Immunophenotyping / Coronavirus Infections / Influenza, Human / Betacoronavirus Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2020 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: Influenza A virus / Pneumonia, Viral / Severity of Illness Index / Interferon Type I / Immunophenotyping / Coronavirus Infections / Influenza, Human / Betacoronavirus Type of study: Prognostic study Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Year: 2020 Document Type: Article