Interleukin-6 receptor blockade with subcutaneous tocilizumab in severe COVID-19 pneumonia and hyperinflammation: a case-control study.

Potere, Nicola; Di Nisio, Marcello; Cibelli, Donatella; Scurti, Rosa; Frattari, Antonella; Porreca, Ettore; Abbate, Antonio; Parruti, Giustino

Potere, Nicola; Di Nisio, Marcello; Cibelli, Donatella; Scurti, Rosa; Frattari, Antonella; Porreca, Ettore; Abbate, Antonio; Parruti, Giustino.

Potere N; Department of Medical, Oral and Biotechnological Sciences, "G D'Annunzio" University, Chieti, Italy.
Di Nisio M; VCU Pauley Heart Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Cibelli D; Department of Medicine and Ageing Sciences, "G' D'Annunzio" University, Chieti-Pescara, Italy.
Scurti R; Department of Vascular Medicine, Amsterdam Medical Center, Amsterdam, The Netherlands.
Frattari A; Infectious Diseases Unit, Pescara General Hospital, Pescara, Italy.
Porreca E; Geriatric Medicine Unit, Pescara General Hospital, Pescara, Italy.
Abbate A; Intensive Care Unit, Pescara General Hospital, Pescara, Italy.
Parruti G; Department of Medical, Oral and Biotechnological Sciences, "G D'Annunzio" University, Chieti, Italy.

Ann Rheum Dis ; 80(2): 1-2, 2021 02.

Article in English | MEDLINE | ID: covidwho-639468

Subject(s)

Antibodies, Monoclonal, Humanized/administration & dosage; COVID-19 Drug Treatment; Receptors, Interleukin-6/immunology; SARS-CoV-2/immunology; Adult; COVID-19/immunology; COVID-19/mortality; Case-Control Studies; Female; Humans; Inflammation; Male; Middle Aged; Retrospective Studies; Treatment Outcome

Keywords

biological therapy; cytokines; immune system diseases; inflammation

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Interleukin-6 / Antibodies, Monoclonal, Humanized / SARS-CoV-2 / COVID-19 Drug Treatment Type of study: Observational study / Prognostic study Limits: Adult / Female / Humans / Male / Middle aged Language: English Journal: Ann Rheum Dis Year: 2021 Document Type: Article Affiliation country: Annrheumdis-2020-218243

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