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SARS-CoV-2 and Male Infertility: Possible Multifaceted Pathology.
Dutta, Sulagna; Sengupta, Pallav.
  • Dutta S; Department of Oral Biology and Biomedical Sciences, Faculty of Dentistry, MAHSA University, Petaling Jaya, Malaysia.
  • Sengupta P; Department of Physiology, Faculty of Medicine, Bioscience and Nursing, MAHSA University, Petaling Jaya, Malaysia. pallav_cu@yahoo.com.
Reprod Sci ; 28(1): 23-26, 2021 01.
Article in English | MEDLINE | ID: covidwho-640228
ABSTRACT
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the coronavirus disease 2019 (COVID-19) has been declared a pandemic by the World Health Organization (WHO) on 11th March 2020. Bulk of research on this virus are carried out to unveil its multivariate pathology. Surprisingly, men are reportedly more vulnerable to COVID-19 even with higher fatality rate compared to women. Thus, it is crucial to determine whether SARS-CoV-2 infection can even affect male fertility as an immediate or long-term consequence of the disease. Among the discrete data available, an important finding is that angiotensin converting enzymes 2 (ACE2) receptor, that aids the SARS-CoV-2 entry into host cells, is profoundly expressed in testicular cells. In addition, the endogenous androgen milieu and its receptors are associated with ACE2 activation reflecting that enhanced testosterone levels may trigger the pathogenesis of COVID-19. In contrary, hypogonadism has also been reported in the acute phase of some COVID-19 cases. Moreover, SARS-CoV-2 infection-induced uncontrolled inflammatory responses may lead to systemic oxidative stress (OS), whose severe disruptive effects on testicular functions are well-documented. This article aims to precisely present the possible impact of COVID-19 on male reproductive functions, and to highlight the speculations that need in-depth research for the exact underlying mechanisms how COVID-19 is associated with men's health and fertility.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Infertility, Male Type of study: Observational study Limits: Humans / Male Language: English Journal: Reprod Sci Journal subject: Reproductive Medicine Year: 2021 Document Type: Article Affiliation country: S43032-020-00261-z

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 / Infertility, Male Type of study: Observational study Limits: Humans / Male Language: English Journal: Reprod Sci Journal subject: Reproductive Medicine Year: 2021 Document Type: Article Affiliation country: S43032-020-00261-z