The renin-angiotensin-aldosterone system: Role in pathogenesis and potential therapeutic target in COVID-19.

Braga, Cássia L; Silva-Aguiar, Rodrigo P; Battaglini, Denise; Peruchetti, Diogo B; Robba, Chiara; Pelosi, Paolo; Rocco, Patricia R M; Caruso-Neves, Celso; Silva, Pedro L

Braga, Cássia L; Silva-Aguiar, Rodrigo P; Battaglini, Denise; Peruchetti, Diogo B; Robba, Chiara; Pelosi, Paolo; Rocco, Patricia R M; Caruso-Neves, Celso; Silva, Pedro L.

Braga CL; Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Silva-Aguiar RP; Laboratory of Biochemistry and Cell Signalling, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Battaglini D; Anesthesia and Intensive Care, Ospedale Policlinico San Martino, IRCCS for Oncology and Neuroscience, Genoa, Italy.
Peruchetti DB; Laboratory of Biochemistry and Cell Signalling, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Robba C; Anesthesia and Intensive Care, Ospedale Policlinico San Martino, IRCCS for Oncology and Neuroscience, Genoa, Italy.
Pelosi P; Anesthesia and Intensive Care, Ospedale Policlinico San Martino, IRCCS for Oncology and Neuroscience, Genoa, Italy.
Rocco PRM; Department of Surgical Sciences and Integrated Diagnostic (DISC), University of Genoa, Genoa, Italy.
Caruso-Neves C; Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Silva PL; National Institute of Science and Technology for Regenerative Medicine, Rio de Janeiro, Brazil.

Pharmacol Res Perspect ; 8(4): e00623, 2020 08.

Article in English | MEDLINE | ID: covidwho-641200

ABSTRACT

ABSTRACT

Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 novel coronavirus, has spread worldwide causing high fatality rates. Neither a vaccine nor specific therapeutic approaches are available, hindering the fight against this disease and making better understanding of its pathogenesis essential. Despite similarities between SARS-CoV-2 and SARS-CoV, the former has unique characteristics which represent a great challenge to physicians. The mechanism of COVID-19 infection and pathogenesis is still poorly understood. In the present review, we highlight possible pathways involved in the pathogenesis of COVID-19 and potential therapeutic targets, focusing on the role of the renin-angiotensin-aldosterone system.

Subject(s)

Betacoronavirus/pathogenicity; Coronavirus Infections/virology; Peptidyl-Dipeptidase A/metabolism; Pneumonia, Viral/virology; Renin-Angiotensin System; Angiotensin Receptor Antagonists/therapeutic use; Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors/therapeutic use; Animals; Antiviral Agents/therapeutic use; Betacoronavirus/drug effects; COVID-19; Coronavirus Infections/diagnosis; Coronavirus Infections/drug therapy; Evidence-Based Medicine; Host-Pathogen Interactions; Humans; Pandemics; Peptidyl-Dipeptidase A/therapeutic use; Pneumonia, Viral/diagnosis; Pneumonia, Viral/drug therapy; Renin-Angiotensin System/drug effects; SARS-CoV-2; COVID-19 Drug Treatment

Keywords

COVID-19; SARS-CoV-2; angiotensin-converting enzyme; inflammation; therapy

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Renin-Angiotensin System / Coronavirus Infections / Peptidyl-Dipeptidase A / Betacoronavirus Type of study: Diagnostic study Topics: Vaccines Limits: Animals / Humans Language: English Journal: Pharmacol Res Perspect Year: 2020 Document Type: Article Affiliation country: Prp2.623

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