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Role of angiotensin-converting enzyme 2 (ACE2) in COVID-19.
Ni, Wentao; Yang, Xiuwen; Yang, Deqing; Bao, Jing; Li, Ran; Xiao, Yongjiu; Hou, Chang; Wang, Haibin; Liu, Jie; Yang, Donghong; Xu, Yu; Cao, Zhaolong; Gao, Zhancheng.
  • Ni W; Department of Pulmonary and Critical Care Medicine, Peking University People's Hospital, Beijing, China.
  • Yang X; Department of Pulmonary and Critical Care Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
  • Yang D; Division of Pulmonary Diseases, State Key Laboratory of Biotherapy of China, and Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China.
  • Bao J; Department of Pulmonary and Critical Care Medicine, Peking University People's Hospital, Beijing, China.
  • Li R; Department of Pulmonary and Critical Care Medicine, Peking University People's Hospital, Beijing, China.
  • Xiao Y; Department of Emergency, The 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Lanzhou, China.
  • Hou C; Department of Cardiology, Peking University People's Hospital, Beijing, China.
  • Wang H; Department of Endocrinology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
  • Liu J; Department of Vascular and Endovascular Surgery, Chinese PLA General Hospital, Beijing, China.
  • Yang D; Department of Pulmonary and Critical Care Medicine, Peking University People's Hospital, Beijing, China.
  • Xu Y; Department of Pulmonary and Critical Care Medicine, Peking University People's Hospital, Beijing, China. lizard_xy@163.com.
  • Cao Z; Department of Pulmonary and Critical Care Medicine, Peking University People's Hospital, Beijing, China. dragonczl@263.net.
  • Gao Z; Department of Pulmonary and Critical Care Medicine, Peking University People's Hospital, Beijing, China. zcgao@bjmu.edu.cn.
Crit Care ; 24(1): 422, 2020 07 13.
Article in English | MEDLINE | ID: covidwho-641221
ABSTRACT
An outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that started in Wuhan, China, at the end of 2019 has become a global pandemic. Both SARS-CoV-2 and SARS-CoV enter host cells via the angiotensin-converting enzyme 2 (ACE2) receptor, which is expressed in various human organs. We have reviewed previously published studies on SARS and recent studies on SARS-CoV-2 infection, named coronavirus disease 2019 (COVID-19) by the World Health Organization (WHO), confirming that many other organs besides the lungs are vulnerable to the virus. ACE2 catalyzes angiotensin II conversion to angiotensin-(1-7), and the ACE2/angiotensin-(1-7)/MAS axis counteracts the negative effects of the renin-angiotensin system (RAS), which plays important roles in maintaining the physiological and pathophysiological balance of the body. In addition to the direct viral effects and inflammatory and immune factors associated with COVID-19 pathogenesis, ACE2 downregulation and the imbalance between the RAS and ACE2/angiotensin-(1-7)/MAS after infection may also contribute to multiple organ injury in COVID-19. The SARS-CoV-2 spike glycoprotein, which binds to ACE2, is a potential target for developing specific drugs, antibodies, and vaccines. Restoring the balance between the RAS and ACE2/angiotensin-(1-7)/MAS may help attenuate organ injuries. SARS-CoV-2 enters lung cells via the ACE2 receptor. The cell-free and macrophage-phagocytosed virus can spread to other organs and infect ACE2-expressing cells at local sites, causing multi-organ injury.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Peptidyl-Dipeptidase A Topics: Vaccines Limits: Humans Language: English Journal: Crit Care Year: 2020 Document Type: Article Affiliation country: S13054-020-03120-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Peptidyl-Dipeptidase A Topics: Vaccines Limits: Humans Language: English Journal: Crit Care Year: 2020 Document Type: Article Affiliation country: S13054-020-03120-0