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Viral CpG Deficiency Provides No Evidence That Dogs Were Intermediate Hosts for SARS-CoV-2.
Pollock, David D; Castoe, Todd A; Perry, Blair W; Lytras, Spyros; Wade, Kristen J; Robertson, David L; Holmes, Edward C; Boni, Maciej F; Kosakovsky Pond, Sergei L; Parry, Rhys; Carlton, Elizabeth J; Wood, James L N; Pennings, Pleuni S; Goldstein, Richard A.
  • Pollock DD; Department of Biochemistry & Molecular Genetics, University of Colorado School of Medicine, Aurora, CO.
  • Castoe TA; Department of Biology, University of Texas Arlington, Arlington, TX.
  • Perry BW; Department of Biology, University of Texas Arlington, Arlington, TX.
  • Lytras S; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom.
  • Wade KJ; Department of Biochemistry & Molecular Genetics, University of Colorado School of Medicine, Aurora, CO.
  • Robertson DL; MRC-University of Glasgow Centre for Virus Research (CVR), Glasgow, United Kingdom.
  • Holmes EC; Marie Bashir Institute for Infectious Diseases & Biosecurity, School of Life & Environmental Sciences and School of Medical Sciences, The University of Sydney, Sydney, NSW, Australia.
  • Boni MF; 5Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, PA.
  • Kosakovsky Pond SL; Institute for Genomics and Evolutionary Medicine, Temple University, Philadelphia, PA.
  • Parry R; Australian Infectious Disease Research Centre, School of Biological Sciences, The University of Queensland, Brisbane, QLD, Australia.
  • Carlton EJ; Department of Environmental and Occupational Health, Colorado School of Public Health, University of Colorado, Anschutz, Aurora, CO.
  • Wood JLN; Disease Dynamics Unit, Department of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.
  • Pennings PS; Department of Biology, San Francisco State University, San Francisco, CA.
  • Goldstein RA; Division of Infection & Immunity, University College London, London, United Kingdom.
Mol Biol Evol ; 37(9): 2706-2710, 2020 09 01.
Article in English | MEDLINE | ID: covidwho-641314
Semantic information from SemMedBD (by NLM)
1. 2019 novel coronavirus PROCESS_OF Ancestor
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Ancestor
2. 2019 novel coronavirus PROCESS_OF Ancestor
Subject
2019 novel coronavirus
Predicate
PROCESS_OF
Object
Ancestor
ABSTRACT
Due to the scope and impact of the COVID-19 pandemic there exists a strong desire to understand where the SARS-CoV-2 virus came from and how it jumped species boundaries to humans. Molecular evolutionary analyses can trace viral origins by establishing relatedness and divergence times of viruses and identifying past selective pressures. However, we must uphold rigorous standards of inference and interpretation on this topic because of the ramifications of being wrong. Here, we dispute the conclusions of Xia (2020. Extreme genomic CpG deficiency in SARS-CoV-2 and evasion of host antiviral defense. Mol Biol Evol. doi10.1093/molbev/masa095) that dogs are a likely intermediate host of a SARS-CoV-2 ancestor. We highlight major flaws in Xia's inference process and his analysis of CpG deficiencies, and conclude that there is no direct evidence for the role of dogs as intermediate hosts. Bats and pangolins currently have the greatest support as ancestral hosts of SARS-CoV-2, with the strong caveat that sampling of wildlife species for coronaviruses has been limited.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Reassortant Viruses / Genome, Viral / Coronavirus Infections / Pandemics / Alphacoronavirus / Betacoronavirus Type of study: Evidence synthesis Limits: Animals / Humans Language: English Journal: Mol Biol Evol Journal subject: Molecular Biology Year: 2020 Document Type: Article Affiliation country: Molbev

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Reassortant Viruses / Genome, Viral / Coronavirus Infections / Pandemics / Alphacoronavirus / Betacoronavirus Type of study: Evidence synthesis Limits: Animals / Humans Language: English Journal: Mol Biol Evol Journal subject: Molecular Biology Year: 2020 Document Type: Article Affiliation country: Molbev