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Virus shedding dynamics in asymptomatic and mildly symptomatic patients infected with SARS-CoV-2.
Li, W; Su, Y-Y; Zhi, S-S; Huang, J; Zhuang, C-L; Bai, W-Z; Wan, Y; Meng, X-R; Zhang, L; Zhou, Y-B; Luo, Y-Y; Ge, S-X; Chen, Y-K; Ma, Y.
  • Li W; Chongqing University Central Hospital, China.
  • Su YY; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen, Fujian, China.
  • Zhi SS; Chongqing University Central Hospital, China.
  • Huang J; Chongqing University Central Hospital, China.
  • Zhuang CL; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen, Fujian, China.
  • Bai WZ; Chongqing University Central Hospital, China.
  • Wan Y; Division of Infectious Diseases, Chongqing Public Health Medical Center, China.
  • Meng XR; Yuzhong District Center for Disease Control and Prevention of Chongqing, Chongqing, China.
  • Zhang L; Division of Infectious Diseases, Chongqing Public Health Medical Center, China.
  • Zhou YB; Yuzhong District Center for Disease Control and Prevention of Chongqing, Chongqing, China.
  • Luo YY; Yuzhong District Center for Disease Control and Prevention of Chongqing, Chongqing, China.
  • Ge SX; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, National Institute of Diagnostics and Vaccine Development in Infectious Diseases, Strait Collaborative Innovation Center of Biomedicine and Pharmaceutics, School of Public Health, Xiamen University, Xiamen, Fujian, China. Elect
  • Chen YK; Division of Infectious Diseases, Chongqing Public Health Medical Center, China. Electronic address: yaokaichen@hotmail.com.
  • Ma Y; Chongqing University Central Hospital, China. Electronic address: 7964yr@sina.com.
Clin Microbiol Infect ; 26(11): 1556.e1-1556.e6, 2020 Nov.
Article in English | MEDLINE | ID: covidwho-919706
ABSTRACT

OBJECTIVES:

Asymptomatic patients, together with those with mild symptoms of coronavirus disease 2019 (COVID-19), may play an important role in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. However, the dynamics of virus shedding during the various phases of the clinical course of COVID-19 remains unclear at this stage.

METHODS:

A total of 18 patients found to be positive for SARS-CoV-2 infection by real-time reverse transcription PCR (RT-PCR) assay and admitted to Chongqing University Central Hospital between 29 January and 5 February 2020 were enrolled into this study. Medical data, pulmonary computed tomographic (CT) scan images and RT-PCR results were periodically collected during the patients' hospital stay. All participants were actively followed up for 2 weeks after discharge.

RESULTS:

A total of nine (50%) asymptomatic patients and nine (50%) patients with mild symptoms of COVID-19 were identified at admission. Six patients (66.7%) who were asymptomatic at admission developed subjective symptoms during hospitalization and were recategorized as being presymptomatic. The median duration of virus shedding was 11.5, 28 and 31 days for presymptomatic, asymptomatic and mildly symptomatic patients, separately. Seven patients (38.9%) continued to shed virus after hospital discharge. During the convalescent phase, detectable antibodies to SARS-CoV-2 and RNA were simultaneously observed in five patients (27.8%).

CONCLUSIONS:

Long-term virus shedding was documented in patients with mild symptoms and in asymptomatic patients. Specific antibody production to SARS-CoV-2 may not guarantee virus clearance after discharge. These observations should be considered when making decisions regarding clinical and public health, and when considering strategies for the prevention and control of SARS-CoV-2 infection.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Virus Shedding / Coronavirus Infections / Asymptomatic Infections / Betacoronavirus Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Clin Microbiol Infect Journal subject: Communicable Diseases / Microbiology Year: 2020 Document Type: Article Affiliation country: J.cmi.2020.07.008

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Virus Shedding / Coronavirus Infections / Asymptomatic Infections / Betacoronavirus Type of study: Diagnostic study / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Adult / Female / Humans / Male / Middle aged Country/Region as subject: Asia Language: English Journal: Clin Microbiol Infect Journal subject: Communicable Diseases / Microbiology Year: 2020 Document Type: Article Affiliation country: J.cmi.2020.07.008