Coronavirus infection and immune system: An insight of COVID-19 in cancer patients.
Crit Rev Oncol Hematol
; 153: 103059, 2020 Sep.
Article
in English
| MEDLINE | ID: covidwho-642053
ABSTRACT
The novel coronavirus respiratory illness (COVID-19) is a public health emergency of global concern. Patients with cancer are at high risk of infections, due to an overall immunocompromised status. However, this connection is not straightforward for coronavirus (CoV) infection, in which the host immune response is the main driver of tissue damage. We performed a thorough review of data on CoV pathogenesis and morbidity rate in cancer patients, through the analysis of the previous CoV pandemics. Considering the interaction between CoV and the host immune system, cancer patients receiving immunotherapy might be more at risk for an aberrant immune response in case of infection, and might therefore deserve additional precautions. The limited available data do not allow us to provide practical indications for the management of cancer patients in this critical situation. Efforts should be made to prospectively collect data, to identify effective interventions to guide treatment decision.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Immunocompromised Host
/
Coronavirus Infections
/
Betacoronavirus
/
Neoplasms
Type of study:
Observational study
/
Prognostic study
Topics:
Long Covid
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Crit Rev Oncol Hematol
Journal subject:
Hematology
/
Neoplasms
Year:
2020
Document Type:
Article
Affiliation country:
J.critrevonc.2020.103059
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