Epidemiological, comorbidity factors with severity and prognosis of COVID-19: a systematic review and meta-analysis.
Aging (Albany NY)
; 12(13): 12493-12503, 2020 07 13.
Article
in English
| MEDLINE | ID: covidwho-642633
ABSTRACT
A systematic review and meta-analysis was conducted in an attempt to systematically collect and evaluate the associations of epidemiological, comorbidity factors with the severity and prognosis of coronavirus disease 2019 (COVID-19). The systematic review and meta-analysis was conducted according to the guidelines proposed by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Sixty nine publications met our study criteria, and 61 studies with more than 10,000 COVID-19 cases were eligible for the quantitative synthesis. We found that the males had significantly higher disease severity (RR 1.20, 95% CI 1.13-1.27, P <0.001) and more prognostic endpoints. Older age was found to be significantly associated with the disease severity and six prognostic endpoints. Chronic kidney disease contributed mostly for death (RR 7.10, 95% CI 3.14-16.02), chronic obstructive pulmonary disease (COPD) for disease severity (RR 4.20, 95% CI 2.82-6.25), admission to intensive care unit (ICU) (RR 5.61, 95% CI 2.68-11.76), the composite endpoint (RR 8.52, 95% CI 4.36-16.65,), invasive ventilation (RR 6.53, 95% CI 2.70-15.84), and disease progression (RR 7.48, 95% CI 1.60-35.05), cerebrovascular disease for acute respiratory distress syndrome (ARDS) (RR 3.15, 95% CI 1.23-8.04), coronary heart disease for cardiac abnormality (RR 5.37, 95% CI 1.74-16.54). Our study highlighted that the male gender, older age and comorbidities owned strong epidemiological evidence of associations with the severity and prognosis of COVID-19.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
/
Reviews
/
Systematic review/Meta Analysis
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
English
Journal:
Aging (Albany NY)
Journal subject:
Geriatrics
Year:
2020
Document Type:
Article
Affiliation country:
Aging.103579
Similar
MEDLINE
...
LILACS
LIS