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Increasing host cellular receptor-angiotensin-converting enzyme 2 expression by coronavirus may facilitate 2019-nCoV (or SARS-CoV-2) infection.
Zhuang, Meng-Wei; Cheng, Yun; Zhang, Jing; Jiang, Xue-Mei; Wang, Li; Deng, Jian; Wang, Pei-Hui.
  • Zhuang MW; Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, China.
  • Cheng Y; School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong.
  • Zhang J; Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, China.
  • Jiang XM; Jinan Infectious Diseases Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
  • Wang L; Jinan Infectious Diseases Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.
  • Deng J; School of Biomedical Sciences, The University of Hong Kong, Pokfulam, Hong Kong.
  • Wang PH; Advanced Medical Research Institute, Cheeloo College of Medicine, Shandong University, Jinan, China.
J Med Virol ; 92(11): 2693-2701, 2020 11.
Article in English | MEDLINE | ID: covidwho-942394
ABSTRACT
The ongoing outbreak of a new coronavirus (2019-nCoV, or severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2]) has caused an epidemic of the acute respiratory syndrome known as coronavirus disease (COVID-19) in humans. SARS-CoV-2 rapidly spread to multiple regions of China and multiple other countries, posing a serious threat to public health. The spike (S) proteins of SARS-CoV-1 and SARS-CoV-2 may use the same host cellular receptor, angiotensin-converting enzyme 2 (ACE2), for entering host cells. The affinity between ACE2 and the SARS-CoV-2 S protein is much higher than that of ACE2 binding to the SARS-CoV S protein, explaining why SARS-CoV-2 seems to be more readily transmitted from human to human. Here, we report that ACE2 can be significantly upregulated after infection of various viruses, including SARS-CoV-1 and SARS-CoV-2, or by the stimulation with inflammatory cytokines such as interferons. We propose that SARS-CoV-2 may positively induce its cellular entry receptor, ACE2, to accelerate its replication and spread; high inflammatory cytokine levels increase ACE2 expression and act as high-risk factors for developing COVID-19, and the infection of other viruses may increase the risk of SARS-CoV-2 infection. Therefore, drugs targeting ACE2 may be developed for the future emerging infectious diseases caused by this cluster of coronaviruses.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Virus / Spike Glycoprotein, Coronavirus / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: J Med Virol Year: 2020 Document Type: Article Affiliation country: Jmv.26139

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Receptors, Virus / Spike Glycoprotein, Coronavirus / Angiotensin-Converting Enzyme 2 / SARS-CoV-2 / COVID-19 Type of study: Prognostic study Limits: Humans Language: English Journal: J Med Virol Year: 2020 Document Type: Article Affiliation country: Jmv.26139