Opioid Use Disorder and COVID-19: Biological Plausibility for Worsened Outcomes.
Subst Use Misuse
; 55(11): 1900-1901, 2020.
Article
in English
| MEDLINE | ID: covidwho-643514
ABSTRACT
BACKGROUND:
Alarms have been raised that COVID-19 may disproportionately affect certain populations with substance use disorders, particularly Opioid Use Disorder (OUD), however warnings have largely focused on social risks such as reduced availability of services.Objectives:
This commentary highlights three plausible biological mechanisms for potentially worsened outcomes in patients with OUD who contract COVID-19.Results:
Opioid-related respiratory depression may amplify risks of hypoxemia from COVID-19 viral pneumonia. Complex opioid immune modulation may impact host response to COVID-19, though the effect direction and clinical significance are unclear. Drug-drug interactions may affect individuals with OUD who are co-administered medications for OUD and medications for COVID-19, particularly due to cardiac adverse effects. Conclusions/Importance There are plausible biological mechanisms for potentially worsened outcomes in patients with OUD who contract COVID-19; these mechanisms require further study, and should be considered in individuals with OUD.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Arrhythmias, Cardiac
/
Respiratory Insufficiency
/
Immunocompromised Host
/
Coronavirus Infections
/
Analgesics, Opioid
/
Opioid-Related Disorders
Type of study:
Prognostic study
Topics:
Long Covid
Limits:
Humans
Language:
English
Journal:
Subst Use Misuse
Journal subject:
Substance-Related Disorders
Year:
2020
Document Type:
Article
Affiliation country:
10826084.2020.1791184
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