The pivotal role of TMPRSS2 in coronavirus disease 2019 and prostate cancer.

Mollica, Veronica; Rizzo, Alessandro; Massari, Francesco

Mollica, Veronica; Rizzo, Alessandro; Massari, Francesco.

Mollica V; Division of Oncology, S.Orsola-Malpighi Hospital, Bologna, Italy.
Rizzo A; Division of Oncology, S.Orsola-Malpighi Hospital, Bologna, Italy.
Massari F; Division of Oncology, S.Orsola-Malpighi Hospital, Bologna, Italy.

Future Oncol ; 16(27): 2029-2033, 2020 Sep.

Article in English | MEDLINE | ID: covidwho-643633

Subject(s)

Coronavirus Infections/pathology; Peptidyl-Dipeptidase A/metabolism; Pneumonia, Viral/pathology; Prostatic Neoplasms/pathology; Serine Endopeptidases/metabolism; Spike Glycoprotein, Coronavirus/metabolism; Androgens/metabolism; Angiotensin-Converting Enzyme 2; Betacoronavirus/metabolism; Betacoronavirus/pathogenicity; COVID-19; Carcinogenesis/pathology; Coronavirus Infections/drug therapy; Coronavirus Infections/transmission; Coronavirus Infections/virology; Disease Progression; Esters; Estrogens/metabolism; Gabexate/analogs & derivatives; Gabexate/pharmacology; Gabexate/therapeutic use; Gene Expression Regulation, Neoplastic; Guanidines; Humans; Lung/pathology; Lung/virology; Male; Oncogene Proteins, Fusion/genetics; Pandemics; Pneumonia, Viral/drug therapy; Pneumonia, Viral/transmission; Pneumonia, Viral/virology; Polymorphism, Single Nucleotide; Prostate/pathology; Prostatic Neoplasms/genetics; Prostatic Neoplasms/mortality; Protease Inhibitors/pharmacology; Protease Inhibitors/therapeutic use; RNA-Seq; SARS-CoV-2; Serine Endopeptidases/genetics; Virus Internalization/drug effects; COVID-19 Drug Treatment

Keywords

COVID-19; SARS-CoV-2; TMPRSS2; prostate cancer

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Prostatic Neoplasms / Serine Endopeptidases / Coronavirus Infections / Peptidyl-Dipeptidase A / Spike Glycoprotein, Coronavirus Type of study: Prognostic study Language: English Journal: Future Oncol Year: 2020 Document Type: Article Affiliation country: Fon-2020-0571

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