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Posterior reversible encephalopathy syndrome in patients with COVID-19.
Parauda, Sarah C; Gao, Virginia; Gewirtz, Alexandra N; Parikh, Neal S; Merkler, Alexander E; Lantos, Joshua; White, Halina; Leifer, Dana; Navi, Babak B; Segal, Alan Z.
  • Parauda SC; Department of Neurology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America.
  • Gao V; Department of Neurology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America.
  • Gewirtz AN; Department of Neurology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America.
  • Parikh NS; Department of Neurology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America; Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, United States of America.
  • Merkler AE; Department of Neurology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America; Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, United States of America.
  • Lantos J; Department of Radiology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America.
  • White H; Department of Neurology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America.
  • Leifer D; Department of Neurology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America.
  • Navi BB; Department of Neurology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America; Clinical and Translational Neuroscience Unit, Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, United States of America.
  • Segal AZ; Department of Neurology, Weill Cornell Medicine, NewYork-Presbyterian Hospital, United States of America. Electronic address: azs2001@med.cornell.edu.
J Neurol Sci ; 416: 117019, 2020 Sep 15.
Article in English | MEDLINE | ID: covidwho-643653
Semantic information from SemMedBD (by NLM)
1. Posterior reversible encephalopathy syndrome PROCESS_OF Patients
Subject
Posterior reversible encephalopathy syndrome
Predicate
PROCESS_OF
Object
Patients
2. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
3. Severe Acute Respiratory Syndrome PROCESS_OF Patients
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Patients
4. Confusion PRECEDES Posterior reversible encephalopathy syndrome
Subject
Confusion
Predicate
PRECEDES
Object
Posterior reversible encephalopathy syndrome
5. Hypertensive disease PROCESS_OF Patients
Subject
Hypertensive disease
Predicate
PROCESS_OF
Object
Patients
6. Injury of kidney PROCESS_OF Patients
Subject
Injury of kidney
Predicate
PROCESS_OF
Object
Patients
7. Posterior reversible encephalopathy syndrome AFFECTS Blood Pressure
Subject
Posterior reversible encephalopathy syndrome
Predicate
AFFECTS
Object
Blood Pressure
8. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
9. Posterior reversible encephalopathy syndrome PROCESS_OF Patients
Subject
Posterior reversible encephalopathy syndrome
Predicate
PROCESS_OF
Object
Patients
10. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
11. Severe Acute Respiratory Syndrome PROCESS_OF Patients
Subject
Severe Acute Respiratory Syndrome
Predicate
PROCESS_OF
Object
Patients
12. Confusion PRECEDES Posterior reversible encephalopathy syndrome
Subject
Confusion
Predicate
PRECEDES
Object
Posterior reversible encephalopathy syndrome
13. Hypertensive disease PROCESS_OF Patients
Subject
Hypertensive disease
Predicate
PROCESS_OF
Object
Patients
14. Injury of kidney PROCESS_OF Patients
Subject
Injury of kidney
Predicate
PROCESS_OF
Object
Patients
15. Posterior reversible encephalopathy syndrome AFFECTS Blood Pressure
Subject
Posterior reversible encephalopathy syndrome
Predicate
AFFECTS
Object
Blood Pressure
16. Critical Illness PROCESS_OF Patients
Subject
Critical Illness
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

OBJECTIVE:

To report four patients with coronavirus disease 2019 (COVID-19) who developed posterior reversible encephalopathy syndrome (PRES).

METHODS:

Patient data was abstracted from medical records at Weill Cornell Medical Center.

RESULTS:

Four patients with SARS-CoV-2 infection and PRES were identified. The patients' ages ranged from 64 to 74 years, and two were women. All four patients were admitted to the hospital with acute respiratory distress syndrome requiring intensive care unit admission and mechanical ventilation. PRES was diagnosed after persistent confusion, lethargy, new focal neurological deficits, or seizures were noted, with evidence of seizures on electroencephalogram for two of the patients. Imaging confirmed the presence of cerebral vasogenic edema. All four patients had elevated blood pressure and renal injury in the days preceding PRES diagnosis, as well as evidence of systemic inflammation and systemic hypercoagulability. Symptoms of PRES improved with blood pressure control.

CONCLUSIONS:

Our four cases demonstrate the occurrence of PRES in critically-ill patients with COVID-19. PRES should be considered in the differential for acute neurological deficits and seizures in this setting.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Posterior Leukoencephalopathy Syndrome / COVID-19 Type of study: Observational study / Risk factors Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: J Neurol Sci Year: 2020 Document Type: Article Affiliation country: J.jns.2020.117019

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Posterior Leukoencephalopathy Syndrome / COVID-19 Type of study: Observational study / Risk factors Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: J Neurol Sci Year: 2020 Document Type: Article Affiliation country: J.jns.2020.117019