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Prevalence, Characteristics, Risk Factors, and Outcomes of Invasively Ventilated COVID-19 Patients with Acute Kidney Injury and Renal Replacement Therapy.
Fominskiy, Evgeny V; Scandroglio, Anna Mara; Monti, Giacomo; Calabrò, Maria Grazia; Landoni, Giovanni; Dell'Acqua, Antonio; Beretta, Luigi; Moizo, Elena; Ravizza, Alfredo; Monaco, Fabrizio; Campochiaro, Corrado; Pieri, Marina; Azzolini, Maria Luisa; Borghi, Giovanni; Crivellari, Martina; Conte, Caterina; Mattioli, Cristina; Silvani, Paolo; Mucci, Milena; Turi, Stefano; Tentori, Stefano; Baiardo Redaelli, Martina; Sartorelli, Marianna; Angelillo, Piera; Belletti, Alessandro; Nardelli, Pasquale; Nisi, Francesco Giuseppe; Valsecchi, Gabriele; Barberio, Cristina; Ciceri, Fabio; Serpa Neto, Ary; Dagna, Lorenzo; Bellomo, Rinaldo; Zangrillo, Alberto.
  • Fominskiy EV; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Scandroglio AM; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Monti G; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Calabrò MG; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Landoni G; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy, landoni.giovanni@hsr.it.
  • Dell'Acqua A; Faculty of Medicine, Vita-Salute San Raffaele University, Milan, Italy, landoni.giovanni@hsr.it.
  • Beretta L; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Moizo E; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Ravizza A; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Monaco F; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Campochiaro C; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Pieri M; Unit of Immunology, Rheumatology, Allergy and Rare Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Azzolini ML; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Borghi G; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Crivellari M; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Conte C; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Mattioli C; Faculty of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
  • Silvani P; Department of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Mucci M; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Turi S; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Tentori S; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Baiardo Redaelli M; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Sartorelli M; Transplant Medicine, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Angelillo P; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Belletti A; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Nardelli P; Department of Hematology and Stem Cell Transplantation, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Nisi FG; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Valsecchi G; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Barberio C; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Ciceri F; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Serpa Neto A; Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Dagna L; Faculty of Medicine, Vita-Salute San Raffaele University, Milan, Italy.
  • Bellomo R; Department of Hematology and Stem Cell Transplantation, IRCCS San Raffaele Scientific Institute, Milan, Italy.
  • Zangrillo A; Australian and New Zealand Intensive Care Research Centre (ANZIC-RC), School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
Blood Purif ; 50(1): 102-109, 2021.
Article in English | MEDLINE | ID: covidwho-643726
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
2. Kidney Failur PROCESS_OF C0030705
Subject
Kidney Failur
Predicate
PROCESS_OF
Object
C0030705
3. Tertiary care hospital LOCATION_OF Observational Study
Subject
Tertiary care hospital
Predicate
LOCATION_OF
Object
Observational Study
4. Chronic Kidney Diseases PROCESS_OF Patients
Subject
Chronic Kidney Diseases
Predicate
PROCESS_OF
Object
Patients
5. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
6. Kidney Failure, Acute PROCESS_OF Patients
Subject
Kidney Failure, Acute
Predicate
PROCESS_OF
Object
Patients
7. Tertiary care hospital LOCATION_OF Observational Study
Subject
Tertiary care hospital
Predicate
LOCATION_OF
Object
Observational Study
8. Chronic Kidney Diseases PROCESS_OF Patients
Subject
Chronic Kidney Diseases
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

BACKGROUND:

There is no information on acute kidney injury (AKI) and continuous renal replacement therapy (CRRT) among invasively ventilated coronavirus disease 2019 (COVID-19) patients in Western healthcare systems.

OBJECTIVE:

To study the prevalence, characteristics, risk factors and outcome of AKI and CRRT among invasively ventilated COVID-19 patients.

METHODS:

Observational study in a tertiary care hospital in Milan, Italy.

RESULTS:

Among 99 patients, 72 (75.0%) developed AKI and 17 (17.7%) received CRRT. Most of the patients developed stage 1 AKI (33 [45.8%]), while 15 (20.8%) developed stage 2 AKI and 24 (33.4%) a stage 3 AKI. Patients who developed AKI or needed CRRT at latest follow-up were older, and among CRRT treated patients a greater proportion had preexisting CKD. Hospital mortality was 38.9% for AKI and 52.9% for CRRT patients.

CONCLUSIONS:

Among invasively ventilated COVID-19 patients, AKI is very common and CRRT use is common. Both carry a high risk of in-hospital mortality.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiration, Artificial / Acute Kidney Injury / Continuous Renal Replacement Therapy / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Blood Purif Year: 2021 Document Type: Article Affiliation country: 000508657

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiration, Artificial / Acute Kidney Injury / Continuous Renal Replacement Therapy / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Long Covid Limits: Aged / Female / Humans / Male / Middle aged Language: English Journal: Blood Purif Year: 2021 Document Type: Article Affiliation country: 000508657