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Probable Vertical Transmission of SARS-CoV-2 Infection.
Demirjian, Alicia; Singh, Cheentan; Tebruegge, Marc; Herbert, Rachel; Draz, Nehal; Mirfenderesky, Mariyam; Jones, Victoria; Hinstridge, Peter; Seneviratne, Ranjika; Myers, Richard; Ellis, Joanna; Miah, Shahjahan; Meadows, Christopher Is; Kenny, Julia; Alonso, Alejandra; Handforth, Jennifer; Perkins, Shona; Butler, Mark; Blackburn, Frances; Douthwaite, Sam; Pillay, Deenan; Chand, Meera; Zambon, Maria.
  • Demirjian A; From the Department of Paediatric Infectious Diseases & Immunology, Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust, London.
  • Singh C; National Infection Service, Public Health England, London.
  • Tebruegge M; Faculty of Life Sciences & Medicine, King's College London, London.
  • Herbert R; Department of Paediatrics and Neonatology, North Middlesex University Hospital NHS Trust, Enfield.
  • Draz N; From the Department of Paediatric Infectious Diseases & Immunology, Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust, London.
  • Mirfenderesky M; Department of Infection, Immunity & Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London.
  • Jones V; Department of Microbiology, North Middlesex University Hospital NHS Trust, Enfield.
  • Hinstridge P; Department of Microbiology, North Middlesex University Hospital NHS Trust, Enfield.
  • Seneviratne R; Department of Infection, Immunity & Inflammation, UCL Great Ormond Street Institute of Child Health, University College London, London.
  • Myers R; Department of Paediatrics and Neonatology, North Middlesex University Hospital NHS Trust, Enfield.
  • Ellis J; Department of Obstetrics and Gynaecology, North Middlesex University Hospital NHS Trust, Enfield.
  • Miah S; Anaesthetic Department, North Middlesex University Hospital NHS Trust, Enfield.
  • Meadows CI; National Infection Service, Public Health England, London.
  • Kenny J; National Infection Service, Public Health England, London.
  • Alonso A; National Infection Service, Public Health England, London.
  • Handforth J; Department of Intensive Care, Guy's and St. Thomas' NHS Foundation Trust, London.
  • Perkins S; From the Department of Paediatric Infectious Diseases & Immunology, Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust, London.
  • Butler M; From the Department of Paediatric Infectious Diseases & Immunology, Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust, London.
  • Blackburn F; From the Department of Paediatric Infectious Diseases & Immunology, Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust, London.
  • Douthwaite S; Directorate of Infection, Guy's and St. Thomas' NHS Foundation Trust, London.
  • Pillay D; Department of General Paediatrics, Evelina London Children's Hospital, Guy's and St. Thomas' NHS Foundation Trust, London.
  • Chand M; Trust Headquarters, North Middlesex University Hospital NHS Trust, Enfield.
  • Zambon M; Directorate of Infection, Guy's and St. Thomas' NHS Foundation Trust, London.
Pediatr Infect Dis J ; 39(9): e257-e260, 2020 09.
Article in English | MEDLINE | ID: covidwho-643742
ABSTRACT

BACKGROUND:

To date, although neonatal infections with severe acute respiratory syndrome coronovirus 2 (SARS-CoV-2) have been described, none of these have been proven to be the result of vertical transmission of SARS-CoV-2.

METHODS:

We describe the probable vertical transmission of SARS-CoV-2 in a neonate born to a mother with coronavirus disease 2019 (COVID-19).

RESULTS:

Following cesarean section, the neonate was kept in strict isolation. Molecular tests for SARS-CoV-2 on respiratory samples, blood, and meconium were initially negative, but positive on a nasopharyngeal aspirate on the third day of life. On day 5, the neonate developed fever and coryza, which spontaneously resolved. Viral genomic analysis from the mother and neonate showed identical sequences except for 1 nucleotide.

CONCLUSION:

This report has important implications for infection control and clinical management of pregnant women with COVID-19 and their newborns.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pregnancy Complications, Infectious / Coronavirus Infections / Infectious Disease Transmission, Vertical / Betacoronavirus Type of study: Case report / Prognostic study Limits: Adult / Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: Pediatr Infect Dis J Journal subject: Communicable Diseases / Pediatrics Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pregnancy Complications, Infectious / Coronavirus Infections / Infectious Disease Transmission, Vertical / Betacoronavirus Type of study: Case report / Prognostic study Limits: Adult / Female / Humans / Infant, Newborn / Pregnancy Language: English Journal: Pediatr Infect Dis J Journal subject: Communicable Diseases / Pediatrics Year: 2020 Document Type: Article