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The bio-mission of interleukin-6 in the pathogenesis of COVID-19: A brief look at potential therapeutic tactics.
Abbasifard, Mitra; Khorramdelazad, Hossein.
  • Abbasifard M; Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department of Internal Medicine, Ali-Ibn-Abi-talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.
  • Khorramdelazad H; Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department of Immunology, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran; Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran. Electronic address: khorramdelazad@gmail.com.
Life Sci ; 257: 118097, 2020 Sep 15.
Article in English | MEDLINE | ID: covidwho-644730
ABSTRACT
Interleukin-6 (IL-6), known as an inflammatory cytokine, can be involved in many innate and adaptive immune responses. The role of IL-6 in the pathogenesis of the novel coronavirus disease 2019 (COVID-19) has recently received much more attention due to the spread of the virus and its pandemic potential. Cytokine storm is among the most critical pathological events in patients affected with coronaviruses (CoVs), i.e., severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East respiratory syndrome coronavirus (MERS-CoV), and COVID-19, causing inflammation-induced lung injury and also occurring as a result of dysregulation of immune responses to the mentioned viruses. IL-6, along with some other inflammatory cytokines, including IL-1 beta (ß), IL-8, and tumor necrosis factor-alpha (TNF-α), as well as inflammatory chemokines, can significantly contribute to, fever, lymphopenia, coagulation, lung injury, and multi-organ failure (MOF). Therefore, researchers are to explore novel approaches to treat the disease through targeting of IL-6 and its receptors based on prior experience of other disorders. In this review article, the latest findings on the role of IL-6 in the pathogenesis of COVID-19, as well as therapeutic perspectives, were summarized and discussed.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Interleukin-6 / Coronavirus Infections / Betacoronavirus Limits: Humans Language: English Journal: Life Sci Year: 2020 Document Type: Article Affiliation country: J.lfs.2020.118097

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Interleukin-6 / Coronavirus Infections / Betacoronavirus Limits: Humans Language: English Journal: Life Sci Year: 2020 Document Type: Article Affiliation country: J.lfs.2020.118097