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Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses.
Nebigil, Canan G; Moog, Christiane; Vagner, Stéphan; Benkirane-Jessel, Nadia; Smith, Duncan R; Désaubry, Laurent.
  • Nebigil CG; INSERM U 1260, Regenerative Nanomedicine (RNM), FMTS, 11 Rue Humann, 67000, Strasbourg, France.
  • Moog C; INSERM U1109, LabEx TRANSPLANTEX, Fédération Hospitalo-Universitaire (FHU) OMICARE, Fédération de Médecine Translationnelle de Strasbourg (FMTS), University of Strasbourg, Strasbourg, France.
  • Vagner S; Institut Curie, PSL Research University, CNRS UMR 3348, INSERM U1278, Orsay, France; Université Paris-Sud, Université Paris-Saclay, CNRS UMR 3348, INSERM U1278, Orsay, France.
  • Benkirane-Jessel N; INSERM U 1260, Regenerative Nanomedicine (RNM), FMTS, 11 Rue Humann, 67000, Strasbourg, France; Université de Strasbourg, Faculté de Chirurgie Dentaire, Hôpitaux Universitaires de Strasbourg, 8 Rue de Ste Elisabeth, 67000, Strasbourg, France.
  • Smith DR; Institute of Molecular Biosciences, Mahidol University, Salaya, 73170, Thailand.
  • Désaubry L; INSERM U 1260, Regenerative Nanomedicine (RNM), FMTS, 11 Rue Humann, 67000, Strasbourg, France. Electronic address: desaubry@unistra.fr.
Eur J Med Chem ; 203: 112653, 2020 Oct 01.
Article in English | MEDLINE | ID: covidwho-645168
ABSTRACT
Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Repressor Proteins / Biological Products / Coronavirus Infections / Aglaia / Eukaryotic Initiation Factor-4A Topics: Traditional medicine Limits: Animals / Humans Language: English Journal: Eur J Med Chem Year: 2020 Document Type: Article Affiliation country: J.ejmech.2020.112653

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Antiviral Agents / Pneumonia, Viral / Repressor Proteins / Biological Products / Coronavirus Infections / Aglaia / Eukaryotic Initiation Factor-4A Topics: Traditional medicine Limits: Animals / Humans Language: English Journal: Eur J Med Chem Year: 2020 Document Type: Article Affiliation country: J.ejmech.2020.112653