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Impact of chronic liver disease on outcomes of hospitalized patients with COVID-19: A multicentre United States experience.
Hashemi, Nikroo; Viveiros, Kathleen; Redd, Walker D; Zhou, Joyce C; McCarty, Thomas R; Bazarbashi, Ahmad N; Hathorn, Kelly E; Wong, Danny; Njie, Cheikh; Shen, Lin; Chan, Walter W.
  • Hashemi N; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA.
  • Viveiros K; Harvard Medical School, Boston, MA, USA.
  • Redd WD; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA.
  • Zhou JC; Harvard Medical School, Boston, MA, USA.
  • McCarty TR; Harvard Medical School, Boston, MA, USA.
  • Bazarbashi AN; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
  • Hathorn KE; Harvard Medical School, Boston, MA, USA.
  • Wong D; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA.
  • Njie C; Harvard Medical School, Boston, MA, USA.
  • Shen L; Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women's Hospital, Boston, MA, USA.
  • Chan WW; Harvard Medical School, Boston, MA, USA.
Liver Int ; 40(10): 2515-2521, 2020 10.
Article in English | MEDLINE | ID: covidwho-645258
ABSTRACT
Liver injury has been described with COVID-19, and early reports suggested 2%-11% of patients had chronic liver disease (CLD). In this multicentre retrospective study, we evaluated hospitalized adults with laboratory-confirmed COVID-19 and the impact of CLD on relevant clinical outcomes. Of 363 patients included, 19% had CLD, including 15.2% with NAFLD. Patients with CLD had longer length of stay. After controlling for age, gender, obesity, cardiac diseases, hypertension, hyperlipidaemia, diabetes and pulmonary disorders, CLD and NAFLD were independently associated with ICU admission ([aOR 1.77, 95% CI 1.03-3.04] and [aOR 2.30, 95% CI 1.27-4.17]) and mechanical ventilation ([aOR 2.08, 95% CI 1.20-3.60] and [aOR 2.15, 95% CI 1.18-3.91]). Presence of cirrhosis was an independent predictor of mortality (aOR 12.5, 95% CI 2.16-72.5). Overall, nearly one-fifth of hospitalized COVID-19 patients had CLD, which was associated with more critical illness. Future studies are needed to identify interventions to improve clinical outcomes.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Critical Illness / SARS-CoV-2 / COVID-19 / Liver Cirrhosis Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Liver Int Journal subject: Gastroenterology Year: 2020 Document Type: Article Affiliation country: Liv.14583

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Critical Illness / SARS-CoV-2 / COVID-19 / Liver Cirrhosis Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid Limits: Female / Humans / Male / Middle aged Country/Region as subject: North America Language: English Journal: Liver Int Journal subject: Gastroenterology Year: 2020 Document Type: Article Affiliation country: Liv.14583