Impact of salt substitute and stepwise reduction of salt supply on blood pressure in residents in senior residential facilities: Design and rationale of the DECIDE-Salt trial.
Am Heart J
; 226: 198-205, 2020 08.
Article
in English
| MEDLINE | ID: covidwho-645275
ABSTRACT
BACKGROUND:
High sodium intake has been considered as the leading dietary risk factor for deaths and disability-adjusted life-years among older adults. High-quality randomized trials to evaluate the effects of practical sodium reduction strategies are needed.METHODS:
The study is a cluster randomized trial with a 2 × 2 factorial design conducted in 48 senior residential facilities in northern China. These facilities are randomly assigned (1111) to 1 of 4 groups stepwise salt supply control (SSSC) in which 5%-10% of the study salt supply in the institutional kitchens will be reduced every 3â¯months, replacing normal salt with salt substitute (SS); SSSC only; SS only; or neither SSSC nor SS. The interventions last for 2 years with follow-up every 6 months. The primary outcome is the change in systolic blood pressure from baseline to 24â¯months. Secondary outcomes include the incidence of hyperkalemia, hyponatremia, cardiovascular events, and death. CURRENT STATUS The study has recruited and randomized 48 senior residential facilities with 1,606 participants. Mean age at baseline was 71â¯years, and 76% are male. Both types of salt intervention were initiated in the study facilities between January and April 2018.CONCLUSION:
The study is well placed to define the effects of 2 practical and scalable sodium reduction strategies for blood pressure reduction and will provide important new data about safety of these strategies among older adults in China.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Blood Pressure
/
Randomized Controlled Trials as Topic
/
Sodium Chloride, Dietary
/
Diet, Sodium-Restricted
/
Flavoring Agents
Type of study:
Cohort study
/
Experimental Studies
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Observational study
/
Prognostic study
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Randomized controlled trials
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Am Heart J
Year:
2020
Document Type:
Article
Affiliation country:
J.ahj.2020.05.013
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