Why the elderly appear to be more severely affected by COVID-19: The potential role of immunosenescence and CMV.
Rev Med Virol
; 30(5): e2144, 2020 09.
Article
in English
| MEDLINE | ID: covidwho-645890
ABSTRACT
The significantly higher mortality rates seen in the elderly compared with young children during the coronavirus disease 2019 (Covid-19) pandemic is likely to be driven in part by an impaired immune response in older individuals. Cytomegalovirus (CMV) seroprevalence approaches 80% in the elderly. CMV has been shown to accelerate immune ageing by affecting peripheral blood T cell phenotypes and increasing inflammatory mediated cytokines such as IL-6. The elderly with pre-existing but clinically silent CMV infection may therefore be particularly susceptible to severe Covid-19 disease and succumb to a cytokine storm which may have been promoted by CMV. Here, we evaluate the potential role of CMV in those with severe Covid-19 disease and consider how this relationship can be investigated in current research studies.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Coronavirus Infections
/
Cytomegalovirus Infections
/
Cytomegalovirus
/
Pandemics
/
Immunosenescence
/
Betacoronavirus
/
Cytokine Release Syndrome
Type of study:
Experimental Studies
/
Observational study
/
Prognostic study
Limits:
Aged
/
Child
/
Humans
Language:
English
Journal:
Rev Med Virol
Journal subject:
Virology
Year:
2020
Document Type:
Article
Affiliation country:
Rmv.2144
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