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Alteration of Liver Biomarkers in Patients with SARS-CoV-2 (COVID-19).
Gholizadeh, Pourya; Safari, Rohollah; Marofi, Parham; Zeinalzadeh, Elham; Pagliano, Pasquale; Ganbarov, Khudaverdi; Esposito, Silvano; Khodadadi, Ehsaneh; Yousefi, Mehdi; Samadi Kafil, Hossein.
  • Gholizadeh P; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Safari R; Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Marofi P; Department of Microbiology, Imam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Zeinalzadeh E; Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Pagliano P; Hematology and Oncology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Ganbarov K; Department of Medicine, University of Salerno, Salerno, Italy.
  • Esposito S; Department of Microbiology, Baku State University, Baku, Republic of Azerbaijan.
  • Khodadadi E; Department of Medicine, University of Salerno, Salerno, Italy.
  • Yousefi M; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Samadi Kafil H; Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
J Inflamm Res ; 13: 285-292, 2020.
Article in English | MEDLINE | ID: covidwho-646404
Semantic information from SemMedBD (by NLM)
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6. Alanine Aminotransferase Increased PROCESS_OF Patients
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Alanine Aminotransferase Increased
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ABSTRACT

INTRODUCTION:

Coronavirus disease 2019 (COVID-19) emerged in China and spread worldwide. In this study, we assessed the characteristics of markers of the liver in patients with COVID-19 to provide new insights in improving clinical treatment. PATIENTS AND

METHODS:

We recruited 279 patients who confirmed COVID-19 and the data of liver biomarkers and complete blood count of patients were defined as the day onset when the patients admitted to the hospital.

RESULTS:

The average of LDH value was 621.29 U/L in all patients with COVID-19, and CPK was 286.90 U/L. The average AST was 44.03 U/L in all patients, and ALT was 31.14 U/L. The AST/ALT ratio was 1.64 in all patients. The measurement of CRP was increased by 79.93% in all patients. Average ALT and AST values of patients with elevated ALT were significantly increased in comparison to patients with normal ALT (P-value = 0.001), while AST/ALT ratio was significantly decreased compared to patients with normal ALT (P-value= 0.014). In addition, the average LDH of patients with elevated ALT was significantly increased compared to patients with normal ALT (P-value = 0.014).

CONCLUSION:

Hepatic injury and abnormal liver enzymes related to COVID-19 infection is an acute non-specific inflammation alteration.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: J Inflamm Res Year: 2020 Document Type: Article Affiliation country: Jir.S257078

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study Language: English Journal: J Inflamm Res Year: 2020 Document Type: Article Affiliation country: Jir.S257078