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Comprehensive mapping of immune perturbations associated with severe COVID-19.
Kuri-Cervantes, Leticia; Pampena, M Betina; Meng, Wenzhao; Rosenfeld, Aaron M; Ittner, Caroline A G; Weisman, Ariel R; Agyekum, Roseline S; Mathew, Divij; Baxter, Amy E; Vella, Laura A; Kuthuru, Oliva; Apostolidis, Sokratis A; Bershaw, Luanne; Dougherty, Jeanette; Greenplate, Allison R; Pattekar, Ajinkya; Kim, Justin; Han, Nicholas; Gouma, Sigrid; Weirick, Madison E; Arevalo, Claudia P; Bolton, Marcus J; Goodwin, Eileen C; Anderson, Elizabeth M; Hensley, Scott E; Jones, Tiffanie K; Mangalmurti, Nilam S; Luning Prak, Eline T; Wherry, E John; Meyer, Nuala J; Betts, Michael R.
  • Kuri-Cervantes L; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Pampena MB; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Meng W; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Rosenfeld AM; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Ittner CAG; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA19104, USA.
  • Weisman AR; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, Philadelphia, PA19104, USA.
  • Agyekum RS; Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Mathew D; Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Baxter AE; Division of Pulmonary, Allergy and Critical Care, Center for Translational Lung Biology, Lung Biology Institute, Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Vella LA; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Kuthuru O; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Apostolidis SA; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Bershaw L; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Dougherty J; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Greenplate AR; Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, 19104, USA.
  • Pattekar A; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Kim J; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Han N; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Gouma S; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Weirick ME; Division of Rheumatology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA.
  • Arevalo CP; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Bolton MJ; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Goodwin EC; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Anderson EM; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Hensley SE; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Jones TK; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Mangalmurti NS; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Luning Prak ET; Division of Gastroenterology, Department of Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA.
  • Wherry EJ; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
  • Meyer NJ; Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
  • Betts MR; Institute for Immunology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Sci Immunol ; 5(49)2020 07 15.
Article in English | MEDLINE | ID: covidwho-646575
Semantic information from SemMedBD (by NLM)
1. Moderate severity PROCESS_OF Patients
Subject
Moderate severity
Predicate
PROCESS_OF
Object
Patients
2. granulocyte LOCATION_OF T-Cell Activation
Subject
granulocyte
Predicate
LOCATION_OF
Object
T-Cell Activation
3. Lymphocyte LOCATION_OF T-Cell Activation
Subject
Lymphocyte
Predicate
LOCATION_OF
Object
T-Cell Activation
4. Dysregulated host response COEXISTS_WITH Severe infection
Subject
Dysregulated host response
Predicate
COEXISTS_WITH
Object
Severe infection
5. Moderate severity PROCESS_OF Patients
Subject
Moderate severity
Predicate
PROCESS_OF
Object
Patients
6. granulocyte LOCATION_OF T-Cell Activation
Subject
granulocyte
Predicate
LOCATION_OF
Object
T-Cell Activation
7. Lymphocyte LOCATION_OF T-Cell Activation
Subject
Lymphocyte
Predicate
LOCATION_OF
Object
T-Cell Activation
8. Dysregulated host response COEXISTS_WITH Severe infection
Subject
Dysregulated host response
Predicate
COEXISTS_WITH
Object
Severe infection
ABSTRACT
Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified extensive induction and activation of multiple immune lineages, including T cell activation, oligoclonal plasmablast expansion, and Fc and trafficking receptor modulation on innate lymphocytes and granulocytes, that distinguished severe COVID-19 cases from healthy donors or SARS-CoV-2-recovered or moderate severity patients. We found the neutrophil to lymphocyte ratio to be a prognostic biomarker of disease severity and organ failure. Our findings demonstrate broad innate and adaptive leukocyte perturbations that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / T-Lymphocytes / B-Lymphocyte Subsets / Coronavirus Infections / Betacoronavirus / Neutrophils Type of study: Prognostic study / Risk factors Limits: Aged / Female / Humans / Male / Middle aged Language: English Year: 2020 Document Type: Article Affiliation country: Sciimmunol.abd7114

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / T-Lymphocytes / B-Lymphocyte Subsets / Coronavirus Infections / Betacoronavirus / Neutrophils Type of study: Prognostic study / Risk factors Limits: Aged / Female / Humans / Male / Middle aged Language: English Year: 2020 Document Type: Article Affiliation country: Sciimmunol.abd7114