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A Low Viral Dose in COVID-19 Patient: A Case Report.
Li, Yajuan; Hu, Xianwei; Tu, Youhui; Wu, Tao; Wang, Bo; Ma, Huan; Zeng, Weihong; Zhao, Dan; Mengist, Hylemariam Mihiretie; Kombe, Arnaud John Kombe; Zheng, Meijuan; Xu, Yuanhong; Jin, Tengchuan.
  • Li Y; Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Hu X; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Tu Y; Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Wu T; Department of Nuclear Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Wang B; Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Ma H; Hefei National Laboratory for Physical Sciences at Microscale, Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
  • Zeng W; Hefei National Laboratory for Physical Sciences at Microscale, Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
  • Zhao D; Hefei National Laboratory for Physical Sciences at Microscale, Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
  • Mengist HM; Hefei National Laboratory for Physical Sciences at Microscale, Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
  • Kombe AJK; Hefei National Laboratory for Physical Sciences at Microscale, Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
  • Zheng M; Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Xu Y; Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
  • Jin T; Hefei National Laboratory for Physical Sciences at Microscale, Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
Front Public Health ; 8: 339, 2020.
Article in English | MEDLINE | ID: covidwho-646611
ABSTRACT
SARS-CoV-2 outbreak has attracted global attention. Verifying the presence of viral RNA is the gold standard for the diagnosis of COVID-19. However, RT-qPCR diagnosis often fails to catch infected patients, because of inconsistent swab sample collection. Here we report a case that showed 5 consecutive negative and 1 low-viral- dose RT-qPCR results during illness spanning over 20 days. Clinical symptoms suggest SARS-CoV-2 infection with typical ground glass like a lung in computed tomography. SARS-CoV-2 infection was serologically confirmed by the presence of anti-SARS-CoV-2 specific antibodies in patients' serum. Finally, a high level of protective IgG was produced after the patient recovered. Surprisingly, as a barber and a housewife staying at home for the first 2 weeks after the onset of illness, none of the close contacts were infected, showing a case of low viral load and low infectivity in this patient.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Case report / Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Front Public Health Year: 2020 Document Type: Article Affiliation country: Fpubh.2020.00339

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Case report / Diagnostic study / Prognostic study Limits: Humans Language: English Journal: Front Public Health Year: 2020 Document Type: Article Affiliation country: Fpubh.2020.00339