Aging, Male Sex, Obesity, and Metabolic Inflammation Create the Perfect Storm for COVID-19.
Diabetes
; 69(9): 1857-1863, 2020 09.
Article
in English
| MEDLINE | ID: covidwho-646684
ABSTRACT
Coronavirus disease 2019 (COVID-19) is a novel threat that seems to result from the collusion between a new pandemic of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and an existing pandemic of metabolic disease driven by obesity. This Perspective explores the evolving epidemiological, clinical, biological, and molecular evidence to propose an unfolding paradigm in which old age, chronic metabolic disease (such as obesity, type 2 diabetes, and metabolic syndrome), and male biological sex produce a deadly symbiosis of dysregulated immunometabolism and chronic systemic inflammation that intensifies virally induced hyperinflammation associated with SARS-CoV-2 infection. It is intended to inspire new research directions and stimulate funding in this field.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Aging
/
Coronavirus Infections
/
Metabolic Syndrome
/
Diabetes Mellitus, Type 2
/
Inflammation
/
Obesity
Type of study:
Prognostic study
/
Randomized controlled trials
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Diabetes
Year:
2020
Document Type:
Article
Affiliation country:
Dbi19-0023
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