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Transplacental transmission of SARS-CoV-2 infection.
Vivanti, Alexandre J; Vauloup-Fellous, Christelle; Prevot, Sophie; Zupan, Veronique; Suffee, Cecile; Do Cao, Jeremy; Benachi, Alexandra; De Luca, Daniele.
  • Vivanti AJ; Division of Obstetrics and Gynecology, Antoine Béclère Hospital, Paris Saclay University Hospitals, APHP 157 rue de la Porte de Trivaux, 92140, Clamart, France.
  • Vauloup-Fellous C; Division of Virology, Paul Brousse Hospital, Paris Saclay University Hospitals, APHP 12 Avenue Paul Vaillant Couturier, 94800, Villejuif, France.
  • Prevot S; Division of Pathology, Bicetre Hospital, Paris Saclay University Hospitals, APHP, Le Kremlin-Bicêtre, France.
  • Zupan V; Division of Pediatrics and Neonatal Critical Care, Antoine Béclère Hospital, Paris Saclay University Hospitals, APHP 157 rue de la Porte de Trivaux, 92140, Clamart, France.
  • Suffee C; Division of Radiology, Antoine Béclère Hospital, Paris Saclay University Hospitals, APHP 157 rue de la Porte de Trivaux, 92140, Clamart, France.
  • Do Cao J; Division of General Pediatrics, Antoine Béclère Hospital, Paris Saclay University Hospitals, APHP 157 rue de la Porte de Trivaux, 92140, Clamart, France.
  • Benachi A; Division of Obstetrics and Gynecology, Antoine Béclère Hospital, Paris Saclay University Hospitals, APHP 157 rue de la Porte de Trivaux, 92140, Clamart, France.
  • De Luca D; Division of Pediatrics and Neonatal Critical Care, Antoine Béclère Hospital, Paris Saclay University Hospitals, APHP 157 rue de la Porte de Trivaux, 92140, Clamart, France. dm.deluca@icloud.com.
Nat Commun ; 11(1): 3572, 2020 07 14.
Article in English | MEDLINE | ID: covidwho-647071
ABSTRACT
SARS-CoV-2 outbreak is the first pandemic of the century. SARS-CoV-2 infection is transmitted through droplets; other transmission routes are hypothesized but not confirmed. So far, it is unclear whether and how SARS-CoV-2 can be transmitted from the mother to the fetus. We demonstrate the transplacental transmission of SARS-CoV-2 in a neonate born to a mother infected in the last trimester and presenting with neurological compromise. The transmission is confirmed by comprehensive virological and pathological investigations. In detail, SARS-CoV-2 causes (1) maternal viremia, (2) placental infection demonstrated by immunohistochemistry and very high viral load; placental inflammation, as shown by histological examination and immunohistochemistry, and (3) neonatal viremia following placental infection. The neonate is studied clinically, through imaging, and followed up. The neonate presented with neurological manifestations, similar to those described in adult patients.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pregnancy Complications, Infectious / Coronavirus Infections / Infectious Disease Transmission, Vertical / Vasculitis, Central Nervous System Type of study: Case report / Diagnostic study / Prognostic study Limits: Adult / Female / Humans / Male / Infant, Newborn / Pregnancy / Young adult Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2020 Document Type: Article Affiliation country: S41467-020-17436-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Pregnancy Complications, Infectious / Coronavirus Infections / Infectious Disease Transmission, Vertical / Vasculitis, Central Nervous System Type of study: Case report / Diagnostic study / Prognostic study Limits: Adult / Female / Humans / Male / Infant, Newborn / Pregnancy / Young adult Language: English Journal: Nat Commun Journal subject: Biology / Science Year: 2020 Document Type: Article Affiliation country: S41467-020-17436-6