A dissection of SARSCoV2 with clinical implications (Review).
Int J Mol Med
; 46(2): 489-508, 2020 Aug.
Article
in English
| MEDLINE | ID: covidwho-647880
ABSTRACT
We are being confronted with the most consequential pandemic since the Spanish flu of 19181920 to the extent that never before have 4 billion people quarantined simultaneously; to address this global challenge we bring to the forefront the options for medical treatment and summarize SARSCoV2 structure and functions, immune responses and known treatments. Based on literature and our own experience we propose new interventions, including the use of amiodarone, simvastatin, pioglitazone and curcumin. In mild infections (sore throat, cough) we advocate prompt local treatment for the nasopharynx (inhalations; aerosols; nebulizers); for moderate to severe infections we propose a triedandtrue treatment the combination of arginine and ascorbate, administered orally or intravenously. The material is organized in three sections i) Clinical aspects of COVID19; acute respiratory distress syndrome (ARDS); known treatments; ii) Structure and functions of SARSCoV2 and proposed antiviral drugs; iii) The combination of arginineascorbate.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
SARS-CoV-2
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Int J Mol Med
Journal subject:
Molecular Biology
/
Genetics, Medical
Year:
2020
Document Type:
Article
Affiliation country:
Ijmm.2020.4636
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