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Recurrence of positive SARS-CoV-2 viral RNA in recovered COVID-19 patients during medical isolation observation.
Yuan, Bo; Liu, Han-Qing; Yang, Zheng-Rong; Chen, Yong-Xin; Liu, Zhi-Yong; Zhang, Kai; Wang, Cheng; Li, Wei-Xin; An, Ya-Wen; Wang, Jian-Chun; Song, Shuo.
  • Yuan B; Science and Education Department, Shenzhen Samii Medical Center, 1 Jinniu West Road, Pingshan District, Shenzhen, Guangdong Province, China.
  • Liu HQ; Science and Education Department, Shenzhen Samii Medical Center, 1 Jinniu West Road, Pingshan District, Shenzhen, Guangdong Province, China.
  • Yang ZR; HIV/AIDS Control and Prevention Division, Shenzhen Center for Disease Control and Prevention, Shenzhen, China.
  • Chen YX; Science and Education Department, Shenzhen Samii Medical Center, 1 Jinniu West Road, Pingshan District, Shenzhen, Guangdong Province, China.
  • Liu ZY; Science and Education Department, Shenzhen Samii Medical Center, 1 Jinniu West Road, Pingshan District, Shenzhen, Guangdong Province, China.
  • Zhang K; Science and Education Department, Shenzhen Samii Medical Center, 1 Jinniu West Road, Pingshan District, Shenzhen, Guangdong Province, China.
  • Wang C; Science and Education Department, Shenzhen Samii Medical Center, 1 Jinniu West Road, Pingshan District, Shenzhen, Guangdong Province, China.
  • Li WX; Science and Education Department, Shenzhen Samii Medical Center, 1 Jinniu West Road, Pingshan District, Shenzhen, Guangdong Province, China.
  • An YW; Science and Education Department, Shenzhen Samii Medical Center, 1 Jinniu West Road, Pingshan District, Shenzhen, Guangdong Province, China.
  • Wang JC; Science and Education Department, Shenzhen Samii Medical Center, 1 Jinniu West Road, Pingshan District, Shenzhen, Guangdong Province, China. wangjianchun@ssmc-sz.com.
  • Song S; Science and Education Department, Shenzhen Samii Medical Center, 1 Jinniu West Road, Pingshan District, Shenzhen, Guangdong Province, China. songshuo@ssmc-sz.com.
Sci Rep ; 10(1): 11887, 2020 07 17.
Article in English | MEDLINE | ID: covidwho-650165
ABSTRACT
Recently, the recurrence of positive SARS-CoV-2 viral RNA in recovered COVID-19 patients is receiving more attention. Herein we report a cohort study on the follow-up of 182 recovered patients under medical isolation observation. Twenty (10.99%) patients out of the 182 were detected to be SARS-CoV-2 RNA positive (re-positives), although none showed any clinical symptomatic recurrence, indicating that COVID-19 responds well to treatment. Patients aged under 18 years had higher re-positive rates than average, and none of the severely ill patients re-tested positive. There were no significant differences in sex between re-positives and non-re-positives. Notably, most of the re-positives turned negative in the following tests, and all of them carried antibodies against SARS-CoV-2. This indicates that they might not be infectious, although it is still important to perform regular SARS-CoV-2 RNA testing and follow-up for assessment of infectivity. The findings of this study provide information for improving the management of recovered patients, and for differentiating the follow-up of recovered patients with different risk levels.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / RNA, Viral / Coronavirus Infections / Betacoronavirus Type of study: Cohort study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-68782-w

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / RNA, Viral / Coronavirus Infections / Betacoronavirus Type of study: Cohort study / Observational study / Prognostic study Limits: Adolescent / Adult / Aged / Child / Child, preschool / Female / Humans / Infant / Male / Middle aged Language: English Journal: Sci Rep Year: 2020 Document Type: Article Affiliation country: S41598-020-68782-w