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Assessment of neurological manifestations in hospitalized patients with COVID-19.
Luigetti, M; Iorio, R; Bentivoglio, A R; Tricoli, L; Riso, V; Marotta, J; Piano, C; Primiano, G; Zileri Del Verme, L; Lo Monaco, M R; Calabresi, P.
  • Luigetti M; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, UOC Neurologia, Rome, Italy.
  • Iorio R; Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Bentivoglio AR; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, UOC Neurologia, Rome, Italy.
  • Tricoli L; Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Riso V; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, UOC Neurologia, Rome, Italy.
  • Marotta J; Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Piano C; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, UOC Neurologia, Rome, Italy.
  • Primiano G; Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Zileri Del Verme L; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, UOC Neurologia, Rome, Italy.
  • Lo Monaco MR; Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Calabresi P; Fondazione Policlinico Universitario 'A. Gemelli' IRCCS, UOC Neurologia, Rome, Italy.
Eur J Neurol ; 27(11): 2322-2328, 2020 11.
Article in English | MEDLINE | ID: covidwho-650512
ABSTRACT
BACKGROUND AND

PURPOSE:

The objective of this study was to assess the neurological manifestations in a series of consecutive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive patients, comparing their frequency with a population hospitalized in the same period for flu/respiratory symptoms, finally not related to SARS-CoV-2.

METHODS:

Patients with flu/respiratory symptoms admitted to Fondazione Policlinico Gemelli hospital from 14 March 2020 to 20 April 2020 were retrospectively enrolled. The frequency of neurological manifestations of patients with SARS-CoV-2 infection was compared with a control group.

RESULTS:

In all, 213 patients were found to be positive for SARS-CoV-2, after reverse transcriptase polymerase chain reaction on nasal or throat swabs, whilst 218 patients were found to be negative and were used as a control group. Regarding central nervous system manifestations, in SARS-CoV-2-positive patients a higher frequency of headache, hyposmia and encephalopathy always related to systemic conditions (fever or hypoxia) was observed. Furthermore, muscular involvement was more frequent in SARS-CoV-2 infection.

CONCLUSIONS:

Patients with COVID-19 commonly have neurological manifestations but only hyposmia and muscle involvement seem more frequent compared with other flu diseases.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Nervous System Diseases Type of study: Experimental Studies / Observational study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Eur J Neurol Journal subject: Neurology Year: 2020 Document Type: Article Affiliation country: Ene.14444

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Nervous System Diseases Type of study: Experimental Studies / Observational study Topics: Long Covid Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: English Journal: Eur J Neurol Journal subject: Neurology Year: 2020 Document Type: Article Affiliation country: Ene.14444