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Blocking inflammation on the way: Rationale for CXCR2 antagonists for the treatment of COVID-19.
Koenig, Lars M; Boehmer, Daniel F R; Metzger, Philipp; Schnurr, Max; Endres, Stefan; Rothenfusser, Simon.
  • Koenig LM; Division of Clinical Pharmacology, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Boehmer DFR; Division of Clinical Pharmacology, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Metzger P; Division of Clinical Pharmacology, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Schnurr M; Division of Clinical Pharmacology, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Endres S; Division of Clinical Pharmacology, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
  • Rothenfusser S; Division of Clinical Pharmacology, University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.
J Exp Med ; 217(9)2020 09 07.
Article in English | MEDLINE | ID: covidwho-650636
ABSTRACT
An exacerbated and unbalanced immune response may account for the severity of COVID-19, the disease caused by the novel severe acute respiratory syndrome (SARS) coronavirus 2, SARS-CoV-2. In this Viewpoint, we summarize recent evidence for the role of neutrophils in the pathogenesis of COVID-19 and propose CXCR2 inhibition as a promising treatment option to block neutrophil recruitment and activation.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Observational study / Prognostic study Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Jem.20201342

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections / Pandemics / Betacoronavirus Type of study: Observational study / Prognostic study Limits: Humans Language: English Year: 2020 Document Type: Article Affiliation country: Jem.20201342