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Clinical characteristics, laboratory findings, radiographic signs and outcomes of 61,742 patients with confirmed COVID-19 infection: A systematic review and meta-analysis.
Pormohammad, Ali; Ghorbani, Saied; Baradaran, Behzad; Khatami, Alireza; J Turner, Raymond; Mansournia, Mohammad Ali; Kyriacou, Demetrios N; Idrovo, Juan-Pablo; Bahr, Nathan C.
  • Pormohammad A; Department of Biological Sciences, University of Calgary, Calgary, AB, Canada. Electronic address: pormohammadali@yahoo.com.
  • Ghorbani S; Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran.
  • Baradaran B; Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
  • Khatami A; Department of Virology, Faculty of Medicine, Iran University of Medical Science, Tehran, Iran.
  • J Turner R; Department of Biological Sciences, University of Calgary, Calgary, AB, Canada. Electronic address: turnerr@ucalgary.ca.
  • Mansournia MA; Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: mansournia_m@sina.tums.ac.ir.
  • Kyriacou DN; Department of Emergency Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA; Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Idrovo JP; Division of GI, Trauma and Endocrine Surgery, Department of Surgery, University of Colorado, Denver Aurora, Colorado, USA.
  • Bahr NC; Division of Infectious Diseases, Department of Medicine, University of Kansas, Kansas City, KS, USA.
Microb Pathog ; 147: 104390, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-650874
Semantic information from SemMedBD (by NLM)
1. Infected PROCESS_OF Patients
Subject
Infected
Predicate
PROCESS_OF
Object
Patients
2. Symptoms PROCESS_OF Patients
Subject
Symptoms
Predicate
PROCESS_OF
Object
Patients
3. Laboratory LOCATION_OF Analysis
Subject
Laboratory
Predicate
LOCATION_OF
Object
Analysis
4. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
5. Infected PROCESS_OF Patients
Subject
Infected
Predicate
PROCESS_OF
Object
Patients
6. Symptoms PROCESS_OF Patients
Subject
Symptoms
Predicate
PROCESS_OF
Object
Patients
7. Laboratory LOCATION_OF Analysis
Subject
Laboratory
Predicate
LOCATION_OF
Object
Analysis
8. COVID-19 PROCESS_OF Patients
Subject
COVID-19
Predicate
PROCESS_OF
Object
Patients
ABSTRACT

INTRODUCTION:

In the current time where we face a COVID-19 pandemic, there is no vaccine or effective treatment at this time. Therefore, the prevention of COVID-19 and the rapid diagnosis of infected patients is crucial.

METHOD:

We searched all relevant literature published up to February 28, 2020. We used Random-effect models to analyze the appropriateness of the pooled results.

RESULT:

Eighty studies were included in the meta-analysis, including 61,742 patients with confirmed COVID-19 infection. 62.5% (95% CI 54.5-79, p < 0.001) of patients had a history of recent travel endemic area or contact with them. The most common symptoms among COVID-19 infected patients were fever 87% (95% CI 73-93, p < 0.001), and cough 68% (95% CI 55.5-74, p < 0.001)), respectively. The laboratory analysis showed that thrombocytosis was present in 61% (95% CI 41-78, p < 0.001) CRP was elevated in 79% (95% CI 65-91, p < 0.001), and lymphopenia in 57.5% (95% CI 42-79, p < 0.001). The most common radiographic signs were bilateral involvement in 81% (95% CI 62.5-87, p < 0.001), consolidation in 73.5% (95% CI 50.5-91, p < 0.001), and ground-glass opacity 73.5% (95% CI 40-90, p < 0.001) of patients. Case fatality rate (CFR) in <15 years old was 0.6%, in >50 years old was 39.5%, and in all range group was 6%.

CONCLUSIONS:

Fever and cough are the most common symptoms of COVID-19 infection in the literature published to date. Thombocytosis, lymphopenia, and increased CRP were common lab findings although most patients included in the overall analysis did not have laboratory values reported. Among Chinese patients with COVID-19, rates of hospitalization, critical condition, and hospitalization were high in this study, but these findings may be biased by reporting only confirmed cases.
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Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections Type of study: Diagnostic study / Prognostic study / Randomized controlled trials / Reviews / Systematic review Topics: Vaccines Limits: Humans Language: English Journal: Microb Pathog Journal subject: Communicable Diseases / Microbiology Year: 2020 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Coronavirus Infections Type of study: Diagnostic study / Prognostic study / Randomized controlled trials / Reviews / Systematic review Topics: Vaccines Limits: Humans Language: English Journal: Microb Pathog Journal subject: Communicable Diseases / Microbiology Year: 2020 Document Type: Article