Comparing associations between frailty and mortality in hospitalised older adults with or without COVID-19 infection: a retrospective observational study using electronic health records.
Age Ageing
; 50(2): 307-316, 2021 02 26.
Article
in English
| MEDLINE | ID: covidwho-650982
ABSTRACT
BACKGROUND:
The aim of this study was to describe outcomes in hospitalised older people with different levels of frailty and COVID-19 infection.METHODS:
We undertook a single-centre, retrospective cohort study examining COVID-19-related mortality using electronic health records, for older people (65 and over) with frailty, hospitalised with or without COVID-19 infection. Baseline covariates included demographics, early warning scores, Charlson Comorbidity Indices and frailty (Clinical Frailty Scale, CFS), linked to COVID-19 status.FINDINGS:
We analysed outcomes on 1,071 patients with COVID-19 test results (285 (27%) were positive for COVID-19). The mean age at ED arrival was 79.7 and 49.4% were female. All-cause mortality (by 30 days) rose from 9 (not frail) to 33% (severely frail) in the COVID-negative cohort but was around 60% for all frailty categories in the COVID-positive cohort. In adjusted analyses, the hazard ratio for death in those with COVID-19 compared to those without COVID-19 was 7.3 (95% CI 3.00, 18.0) with age, comorbidities and illness severity making small additional contributions.INTERPRETATION:
In this study, frailty measured using the CFS appeared to make little incremental contribution to the hazard of dying in older people hospitalised with COVID-19 infection; illness severity and comorbidity had a modest association with the overall adjusted hazard of death, whereas confirmed COVID-19 infection dominated, with a sevenfold hazard for death.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Geriatric Assessment
/
Frail Elderly
/
Hospital Mortality
/
Frailty
/
COVID-19
Type of study:
Cohort study
/
Diagnostic study
/
Observational study
/
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Europa
Language:
English
Journal:
Age Ageing
Year:
2021
Document Type:
Article
Affiliation country:
Ageing
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