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Temporal dynamics in viral shedding and transmissibility of COVID-19.
He, Xi; Lau, Eric H Y; Wu, Peng; Deng, Xilong; Wang, Jian; Hao, Xinxin; Lau, Yiu Chung; Wong, Jessica Y; Guan, Yujuan; Tan, Xinghua; Mo, Xiaoneng; Chen, Yanqing; Liao, Baolin; Chen, Weilie; Hu, Fengyu; Zhang, Qing; Zhong, Mingqiu; Wu, Yanrong; Zhao, Lingzhai; Zhang, Fuchun; Cowling, Benjamin J; Li, Fang; Leung, Gabriel M.
  • He X; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Lau EHY; World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong, SAR, China. ehylau@hku.hk.
  • Wu P; World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong, SAR, China.
  • Deng X; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Wang J; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Hao X; World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong, SAR, China.
  • Lau YC; World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong, SAR, China.
  • Wong JY; World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong, SAR, China.
  • Guan Y; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Tan X; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Mo X; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Chen Y; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Liao B; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Chen W; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Hu F; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Zhang Q; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Zhong M; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Wu Y; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Zhao L; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Zhang F; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Cowling BJ; World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong, SAR, China.
  • Li F; Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China.
  • Leung GM; World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong, SAR, China.
Nat Med ; 26(5): 672-675, 2020 05.
Article in English | MEDLINE | ID: covidwho-65153
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ABSTRACT
We report temporal patterns of viral shedding in 94 patients with laboratory-confirmed COVID-19 and modeled COVID-19 infectiousness profiles from a separate sample of 77 infector-infectee transmission pairs. We observed the highest viral load in throat swabs at the time of symptom onset, and inferred that infectiousness peaked on or before symptom onset. We estimated that 44% (95% confidence interval, 25-69%) of secondary cases were infected during the index cases' presymptomatic stage, in settings with substantial household clustering, active case finding and quarantine outside the home. Disease control measures should be adjusted to account for probable substantial presymptomatic transmission.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Virus Shedding / Coronavirus Infections / Betacoronavirus Type of study: Observational study Limits: Humans Language: English Journal: Nat Med Journal subject: Molecular Biology / Medicine Year: 2020 Document Type: Article Affiliation country: S41591-020-0869-5

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Virus Shedding / Coronavirus Infections / Betacoronavirus Type of study: Observational study Limits: Humans Language: English Journal: Nat Med Journal subject: Molecular Biology / Medicine Year: 2020 Document Type: Article Affiliation country: S41591-020-0869-5