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Creutzfeldt-Jakob disease in a man with COVID-19: SARS-CoV-2-accelerated neurodegeneration?
Young, Michael J; O'Hare, Meabh; Matiello, Marcelo; Schmahmann, Jeremy D.
  • Young MJ; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, United States. Electronic address: michael.young@mgh.harvard.edu.
  • O'Hare M; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, United States.
  • Matiello M; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, United States.
  • Schmahmann JD; Department of Neurology, Massachusetts General Hospital, Harvard Medical School, United States.
Brain Behav Immun ; 89: 601-603, 2020 10.
Article in English | MEDLINE | ID: covidwho-651618
Semantic information from SemMedBD (by NLM)
1. Creutzfeldt-Jakob disease PROCESS_OF Male population group
Subject
Creutzfeldt-Jakob disease
Predicate
PROCESS_OF
Object
Male population group
2. COVID-19 PROCESS_OF Male population group
Subject
COVID-19
Predicate
PROCESS_OF
Object
Male population group
3. Inflammation Mediators AUGMENTS Prion Diseases
Subject
Inflammation Mediators
Predicate
AUGMENTS
Object
Prion Diseases
4. Creutzfeldt-Jakob disease PROCESS_OF Male population group
Subject
Creutzfeldt-Jakob disease
Predicate
PROCESS_OF
Object
Male population group
5. COVID-19 PROCESS_OF Male population group
Subject
COVID-19
Predicate
PROCESS_OF
Object
Male population group
6. Inflammation Mediators AUGMENTS Prion Diseases
Subject
Inflammation Mediators
Predicate
AUGMENTS
Object
Prion Diseases
ABSTRACT
We describe a man whose first manifestations of Creutzfeldt-Jakob disease occurred in tandem with symptomatic onset of coronavirus disease 2019 (COVID-19). Drawing from recent data on prion disease pathogenesis and immune responses to SARS-CoV-2, we hypothesize that the cascade of systemic inflammatory mediators in response to the virus accelerated the pathogenesis of our patient's prion disease. This hypothesis introduces the potential relationship between immune responses to the novel coronavirus and the hastening of preclinical or manifest neurodegenerative disorders. The global prevalence of both COVID-19 and neurodegenerative disorders adds urgency to the study of this potential relationship.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Brain / Creutzfeldt-Jakob Syndrome / Coronavirus Infections Type of study: Diagnostic study / Risk factors Limits: Aged / Humans / Male Language: English Journal: Brain Behav Immun Journal subject: Allergy and Immunology / Brain / Psychophysiology Year: 2020 Document Type: Article

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Brain / Creutzfeldt-Jakob Syndrome / Coronavirus Infections Type of study: Diagnostic study / Risk factors Limits: Aged / Humans / Male Language: English Journal: Brain Behav Immun Journal subject: Allergy and Immunology / Brain / Psychophysiology Year: 2020 Document Type: Article