Creutzfeldt-Jakob disease in a man with COVID-19: SARS-CoV-2-accelerated neurodegeneration?
Brain Behav Immun
; 89: 601-603, 2020 10.
Article
in English
| MEDLINE | ID: covidwho-651618
ABSTRACT
We describe a man whose first manifestations of Creutzfeldt-Jakob disease occurred in tandem with symptomatic onset of coronavirus disease 2019 (COVID-19). Drawing from recent data on prion disease pathogenesis and immune responses to SARS-CoV-2, we hypothesize that the cascade of systemic inflammatory mediators in response to the virus accelerated the pathogenesis of our patient's prion disease. This hypothesis introduces the potential relationship between immune responses to the novel coronavirus and the hastening of preclinical or manifest neurodegenerative disorders. The global prevalence of both COVID-19 and neurodegenerative disorders adds urgency to the study of this potential relationship.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Pneumonia, Viral
/
Brain
/
Creutzfeldt-Jakob Syndrome
/
Coronavirus Infections
Type of study:
Case report
/
Diagnostic study
/
Observational study
Topics:
Long Covid
/
Variants
Limits:
Aged
/
Humans
/
Male
Language:
English
Journal:
Brain Behav Immun
Journal subject:
Allergy and Immunology
/
Brain
/
Psychophysiology
Year:
2020
Document Type:
Article
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