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The Effect of Age on Mortality in Patients With COVID-19: A Meta-Analysis With 611,583 Subjects.
Bonanad, Clara; García-Blas, Sergio; Tarazona-Santabalbina, Francisco; Sanchis, Juan; Bertomeu-González, Vicente; Fácila, Lorenzo; Ariza, Albert; Núñez, Julio; Cordero, Alberto.
  • Bonanad C; Cardiology Department, Hospital Clínico Universitario, Valencia, Spain; Instituto de Investigación Sanitaria (INCLIVA), Hospital Clínico Universitario de Valencia, Spain.
  • García-Blas S; Cardiology Department, Hospital Clínico Universitario, Valencia, Spain; Instituto de Investigación Sanitaria (INCLIVA), Hospital Clínico Universitario de Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain.
  • Tarazona-Santabalbina F; Servicio de Geriatría, Hospital Universitario de la Ribera, Alzira, Valencia, Spain.
  • Sanchis J; Cardiology Department, Hospital Clínico Universitario, Valencia, Spain; Instituto de Investigación Sanitaria (INCLIVA), Hospital Clínico Universitario de Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain.
  • Bertomeu-González V; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Cardiology Department, Hospital Universitario de San Juan, Alicante, Spain.
  • Fácila L; Cardiology Department, Hospital General Universitario de Valencia, Spain.
  • Ariza A; Cardiology Department, Hospital Clínico Universitario Bellvitge, Hospital De Llobregat, Barcelona, Spain.
  • Núñez J; Cardiology Department, Hospital Clínico Universitario, Valencia, Spain; Instituto de Investigación Sanitaria (INCLIVA), Hospital Clínico Universitario de Valencia, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain.
  • Cordero A; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Cardiology Department, Hospital Universitario de San Juan, Alicante, Spain. Electronic address: acorderofort@gmail.com.
J Am Med Dir Assoc ; 21(7): 915-918, 2020 Jul.
Article in English | MEDLINE | ID: covidwho-651906
ABSTRACT

OBJECTIVES:

Initial data on COVID-19 infection has pointed out a special vulnerability of older adults.

DESIGN:

We performed a meta-analysis with available national reports on May 7, 2020 from China, Italy, Spain, United Kingdom, and New York State. Analyses were performed by a random effects model, and sensitivity analyses were performed for the identification of potential sources of heterogeneity. SETTING AND

PARTICIPANTS:

COVID-19-positive patients reported in literature and national reports.

MEASURES:

All-cause mortality by age.

RESULTS:

A total of 611,1583 subjects were analyzed and 141,745 (23.2%) were aged ≥80 years. The percentage of octogenarians was different in the 5 registries, the lowest being in China (3.2%) and the highest in the United Kingdom and New York State. The overall mortality rate was 12.10% and it varied widely between countries, the lowest being in China (3.1%) and the highest in the United Kingdom (20.8%) and New York State (20.99%). Mortality was <1.1% in patients aged <50 years and it increased exponentially after that age in the 5 national registries. As expected, the highest mortality rate was observed in patients aged ≥80 years. All age groups had significantly higher mortality compared with the immediately younger age group. The largest increase in mortality risk was observed in patients aged 60 to 69 years compared with those aged 50 to 59 years (odds ratio 3.13, 95% confidence interval 2.61-3.76). CONCLUSIONS AND IMPLICATIONS This meta-analysis with more than half million of COVID-19 patients from different countries highlights the determinant effect of age on mortality with the relevant thresholds on age >50 years and, especially, >60 years. Older adult patients should be prioritized in the implementation of preventive measures.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Mortality / Coronavirus Infections / Pandemics Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America / Asia / Europa Language: English Journal: J Am Med Dir Assoc Journal subject: History of Medicine / Medicine Year: 2020 Document Type: Article Affiliation country: J.jamda.2020.05.045

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / Mortality / Coronavirus Infections / Pandemics Type of study: Experimental Studies / Observational study / Prognostic study / Randomized controlled trials / Reviews Limits: Aged / Female / Humans / Male / Middle aged Country/Region as subject: North America / Asia / Europa Language: English Journal: J Am Med Dir Assoc Journal subject: History of Medicine / Medicine Year: 2020 Document Type: Article Affiliation country: J.jamda.2020.05.045